GeneXpert MTB/RIF for rapid diagnosis and rifampin resistance detection of endobronchial tuberculosis

Abstract

GeneXpert MTB/RIF may enable more rapid EBTB diagnosis and determination of RIF resistance, which are crucial for timely treatment.

Xpert MTB/RIF for rapid detection of TB and rifampicin resistance in the evaluation of tracheobronchial lesions: What's to stop its use?

“…Zhang et al . recruited 69 patients who underwent bronchoscopic evaluation for EBTB because of CT thorax findings compatible with this diagnosis.…”

“…In a recent publication in Respirology , Zhang et al . investigated the performance of Xpert MTB/RIF in bronchial brushing and biopsy specimens of patients with endobronchial TB (EBTB) …”

“…In conclusion, the study by Zhang et al . provides evidence that the use of Xpert MTB/RIF in bronchial brushings and biopsy expedites the diagnosis (and therefore treatment) of EBTB, potentially preventing airway stricture formation.…”

“…In a recent publication in Respirology, Zhang et al investigated the performance of Xpert MTB/RIF in bronchial brushing and biopsy specimens of patients with endobronchial TB (EBTB). 4 EBTB refers to tuberculous infection of the tracheobronchial tree and was first described in 1698 by Morton. 5 In a series of 1000 autopsies of patients with TB, Auerbach found microscopic EBTB in 42% and gross EBTB in 22%.…”

“…[8][9][10][11][12]14 Um et al found that duration of symptom onset to initiation of anti-TB treatment of >90 days independently predicted persistent airway stenosis, implying that early initiation of treatment can potentially prevent this undesirable outcome. 15 Zhang et al 4 recruited 69 patients who underwent bronchoscopic evaluation for EBTB because of CT thorax findings compatible with this diagnosis. Of these, 61 were diagnosed EBTB based on bronchoscopic features, histology and positive sputum or tissue TB cultures.…”