“…The idea was to be able to calculate the theoretical fitness required to maintain in equilibrium a given gene frequency in a population of which the gene elimination rate was known. Also in this case, the computations, in any case incorrect in a preliminary work published in Nature in 1954 (Silvestroni et al, 1954), produced controversial results, which made it impossible to adequately demonstrate the advantage of heterozygosis, but nevertheless suggested pursuing research in that direction.…”