Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction

Genipin ameliorates hypertension-induced renal damage via the angiotensin II-TLR/MyD88/MAPK pathway

“…In a rat hippocampal slice cultures study, genipin provided significant protection against tert-butyl hydroperoxide, reduced cell death when administered rotenone which generates ROS, and successfully quenched 1,1-diphenyl-2-picryl-hydrazyl, a stable free radical, suggesting that genipin may act as a direct free radical scavenger [34]. Genipin also inhibited cellular ROS overproduction in hepatocytes [35] and HUVEC [36]. In addition, genipin can induce antioxidative enzymes.…”

“…1), which has been widely used in Traditional Chinese Medicine for the treatment of hypertension, cerebral thrombogenesis, and other cardiovascular diseases [12]. Previous in vitro and in vivo studies have demonstrated that genipin has potent anti-oxidant and anti-inflammatory effects [13,14]. More importantly, it has been documented that genipin can suppress the activation of the MAPK and TLR signaling pathways [15,16].…”

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice

“…Moreover, overexpression of uncoupling protein-2 (UCP2) in the liver can cause acute liver injury [26]. The natural product genipin (GNP), an inhibitor of UCP2, was shown to enhance ATP production in isolated pancreatic islets and improve mitochondrial function in mice [27,28]. UCP2 also suppresses inflammation and inhibits NLRP3 expression [29,30].…”

Phytochemistry, Pharmacological Activities and Intellectual Property Landscape of Gardenia jasminoides Ellis: a Review

“…45 Effects of geniposidic acid on protecting vascular endothelium and reversing plaque formation was elevated. 46 Genipin exerted anti-diabetic activity by improving insulin sensitivity through ameliorating insulin-stimulated glucose update and glycogen synthesis, inhibited overproduction of cellular reactive oxygen species (ROS); reversing hepatic oxidative stress-associated JNK hyperactivation and reduced Akt phosphorylation and alleviating mitochondrial membrane potential (MMP) and mitochondrial ATP dysfunction; 47 promoted glucose transporter 4 (GLUT4) translocation to the cell surface in sub-cellular membrane fraction and amplified the phosphorylation of insulin ROHAN SHARADANAND PHATAK: Phytochemistry, Pharmacology and IP of Gardenia jasminoides Ellis receptor substrate-1 (IRS-1), AKT, and GSK3β to augment ATP levels, closed K (ATP) channels, the concentration of calcium in the cytoplasm in C(2) C(12) myotubes with increases the level of ROS and ATP in myotubes. 48 Crocetin proved its anti-diabetic effect by restoring dexamethasone-induced insulin resistance and related abnormalities in rats 49 by inhibiting pancreatic lipase 50 and malabsorption of fat and cholesterol due to the inhibition of pancreatic lipase and its metabolite, crocetin improved hyperlipidemia.…”