Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

Xu, Bin; Li, Yanli; Xu, Ming; Yu, Chunrong; Lian, Mengqiao; Tang, Zeyao; Li, Chuan-Xun; Lin, Yuan

doi:10.1038/aps.2016.168

Cited by 70 publications

(40 citation statements)

References 45 publications

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“…A recent report demonstrates that geniposide ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced experimental rat colitis by reducing inflammation and modulating the disrupted epithelial barrier function via activating the AMP-activated protein kinase signalling pathway (Xu et al. 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts

Shin¹,

Lee

Huang

et al. 2018

Pharmaceutical Biology

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Context: Geniposide (genipin-1-O-β-d-glucoside) is a major bioactive ingredient in the fruits of gardenia [Gardenia jasminoides J. Ellis (Rubiaceae)], a traditional herbal medicine in Asian countries.Objective: This work assesses the skin anti-photoaging potential of geniposide in human dermal fibroblasts under UV-B irradiation.Materials and methods: The anti-photoaging property of geniposide, at varying concentrations (5, 12 and 30 μM) treated for 30 min prior to UV-B irradiation, was evaluated by analysing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2), glutathione (GSH), superoxide dismutase (SOD), nuclear factor erythroid 2-related factor 2 (Nrf2) and cellular viability.Results: Geniposide suppressed the ROS elevation under UV-B irradiation, which was revealed using three ROS-sensitive fluorescent dyes. The use of 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA), dihydroethidium (DHE) and dihydrorhodamine 123 (DHR-123) elicited the IC50 values of 10.5, 9.8 and 21.0 μM, respectively. Geniposide attenuated proMMP-2 at activity and protein levels that were elevated under UV-B-irradiation. Geniposide at 5, 12 and 30 μM augmented the UV-B-reduced total GSH content to 1.9 ± 0.1-, 2.2 ± 0.2- and 4.1 ± 0.2-fold, respectively. Geniposide at 5, 12 and 30 μM upregulated total SOD activity to 2.3 ± 0.1-, 2.5 ± 0.3- and 3.3 ± 0.3-fold, respectively, under UV-B irradiation. The UV-B-reduced Nrf2 levels were also upregulated by geniposide treatment. Geniposide, at the concentrations used, was unable to interfere with cellular viabilities under UV-B irradiation.Discussion and conclusions: After the skin anti-photoaging potential of geniposide may be further verified, it can be utilized as a safer resource in the manufacture of effective anti-aging cosmetics.

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Section: Discussionmentioning

confidence: 99%

Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts

Shin¹,

Lee

Huang

et al. 2018

Pharmaceutical Biology

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“…Geniposide acid contained in 'Tochu-cha' is known to improve hypertension and hyperlipidemia. 6,7) Previous studies showed that geniposide, which is an iridoid glycosides purified from the fruit of Gardenia jasminoides ELLIS, suppressed inflammatory cytokine (TNF-α and IL-1β) release and neutrophil infiltration (myeloperoxidase activity) in the colitis model. 8) Additionally, Eucommia ulmoides OLIV.…”

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confidence: 99%

Effect of <i>Eucommia ulmoides</i> Leaf Extract on Chronic Dextran Sodium Sulfate-Induced Colitis in Mice

Murakami

Tasaka

Takatori

et al. 2018

Biological & Pharmaceutical Bulletin

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Ulcerative colitis (UC) is a refractory disease that causes chronic inflammation or ulceration in the mucosa of the large intestine with multiple relapses. Although several drugs, including 5-aminosalicylic acid, steroids, immunosuppressants, and infliximab, are used for UC therapy, patients suffer from side effects of these drugs, and a new safer therapeutic agent is desired. Eucommia ulmoides OLIV. leaf extract (ELE) has an anti-inflammatory effect. Therefore, we examined the effect of ELE on UC using a chronic dextran sulfate sodium (DSS)-induced colitis model in mice. Chronic DSS-induced colitis was triggered by alternately repeating 5 days' DSS and 7 days' water administration in mice for 29 d. The severity of DSS-induced colitis was evaluated by daily body weight and bloody stool score, and colon length and myeloperoxidase (MPO) activity in colon tissue on day 29. ELE (3 or 9%) was administered in combination by feeding for 29 d, and the effect on colitis was evaluated. The mice given DSS exhibited chronic colitis symptoms with body weight loss, increased bloody stool score and MPO activity, and shortened colon length. Administration of 3 or 9% ELE suppressed the body weight loss, bloody stool score, colon shortening, and MPO activity in a dose-dependent manner. Histological analysis showed that the ELE-treated mice had less damages and leukocyte infiltration in the mucosal layer of the large intestine compared to DSS alone group. These results suggested that ELE has the potential to prevent the development of DSS-induced colitis and a therapeutic effect on UC in a safe manner.

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“…e amount of geniposide was as follows: GE: 0.154 g/mL. Geniposide has been shown to reduce inflammatory cytokines in intestinal diseases [31]. In this study, we suggest that geniposide may reduce inflammation in reflux esophagitis.…”

Section: Resultsmentioning

confidence: 83%

Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats

Kim

Shin

Lee

et al. 2020

BioMed Research International

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Gardeniae Fructus 50% EtOH extract (GE) is a traditional herb that has been used to treat a variety of diseases. In this study, we investigate the antioxidant, anti-inflammatory, and antiapoptotic properties of GE on acute reflux-induced esophagitis (RE) model in rats. 2,2′-Azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays were performed to determine the antioxidant activity of GE. GE was given orally at 50 and 100 mg/kg body weight 1h 30 min prior to RE induction. And its effect was assessed in comparison with RE control and normal groups. The administration of the extract of the GE showed remarkable protection of mucosal damage in esophageal tissue, and the histologic observation showed that the gastric lesion was improved. Increased reactive oxygen species (ROS) levels in the serum were diminished by GE treatment. The antioxidative biomarkers including nuclear factor-erythroid 2-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) were significantly increased. GE administration significantly reduced the inflammatory protein expression through MAPK-related signaling pathways and the nuclear factor-kappa B (NF-κB) pathway. These results suggest that GE protects the esophagus mucosal membrane by attenuating oxidative stress and inflammatory response under reflux esophagitis condition through the antioxidant pathway. Therefore, it is suggested that GE may be a potential remedy for the treatment of reflux esophagitis.

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Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

Cited by 70 publications

References 45 publications

Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts

Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts

Effect of <i>Eucommia ulmoides</i> Leaf Extract on Chronic Dextran Sodium Sulfate-Induced Colitis in Mice

Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats

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