Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation

Dharmappa, K.K.; Mohamed, Riyaz; Shivaprasad, Holenarasipura V.; Vishwanath, Bannikuppe S.

doi:10.1007/s10787-009-0018-8

Cited by 33 publications

(20 citation statements)

References 31 publications

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“…The chemical substances derived from plants are of potential interest for therapeutic intervention in inflammatory diseases. They act either by inhibiting the proinflammatory enzymes or by inhibition of cytokine release, etc., that are known contributors to chronic inflammatory disorders (Dharmappa et al 2010). Hence, inhibition of pro-inflammatory mediators is legitimate in the neutralization of inflammation.…”

Section: Resultsmentioning

confidence: 99%

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

et al. 2011

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Section: Resultsmentioning

confidence: 99%

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

et al. 2011

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“…Anthocyanidins have been shown to ameliorate cognitive deficits in AD patients and improve immunocompetency of these patients [114]. The polyphenol genistein was shown to be a potent inhibitor of sPLA 2 in inflammatory exudates and in snake venom-induced mouse paw edema [115]. It appears that anti-inflammatory activities of many plant flavonoids are associated with inhibition of PLA 2 [116].…”

Section: Prevention Of Neurodegenerative Diseases By Natural Antioxidmentioning

confidence: 99%

Targeting NADPH Oxidase and Phospholipases A2 in Alzheimer’s Disease

Simonyi

Sheng

et al. 2010

Mol Neurobiol

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Alzheimer’s disease (AD) is marked by an increase in the production of extracellular beta amyloid plaques and intracellular neurofibrillary tangles associated with a decline in brain function. Increases in oxidative stress are regarded as an early sign of AD pathophysiology, although the source of reactive oxygen species (ROS) and the mechanism(s) whereby beta amyloid peptides (Aβ) impact oxidative stress have not been adequately investigated. Recent studies provide strong evidence for the involvement of NADPH oxidase and its downstream oxidative signaling pathways in the toxic effects elicited by Aβ. ROS produced by NADPH oxidase activate multiple signaling pathways leading to neuronal excitotoxicity and glial cell-mediated inflammation. This review describes recent studies demonstrating the neurotoxic effects of Aβ in conjunction with ROS produced by NADPH oxidase and the downstream pathways leading to activation of cytosolic phospholipase A2 (PLA2) and secretory PLA2. In addition, this review also describes recent studies using botanical antioxidants to protect against oxidative damage associated with AD. Investigating the metabolic and signaling pathways involving Aβ NADPH oxidase and PLA2 can help understand the mechanisms underlying the neurodegenerative effects of oxidative stress in AD. This information should provide new therapeutic approaches for prevention of this debilitating disease.

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“…E2 also attenuates TNF-α-induced mRNA expression of inflammatory mediators [198]. Similar to E2, phytoestrogens may exert vascular anti-inflammatory effects, and the anti-inflammatory effect of several medicinal herbs could be due to their phytoestrogen content [199]. Genistein protects against inflammatory factor-induced EC dysfunction and inhibits leukocyte-endothelium interaction [200].…”

Section: Introductionmentioning

confidence: 99%

“…Genistein also reduces mRNA expression levels of E-selectin, CAM-1 and P-selectin which are elicited by the proinflammatory bacterial LPS [59]. Genistein also inhibits the activity of the key inflammatory enzyme secretory phospholipase A2 in mice [199]. Other studies support the anti-inflammatory properties of phytoestrogens and suggest the utilization of these properties in preventing graft rejection [204], treating arthritis [205], protection against UV rays-induced skin inflammation [206] and treating bronchial asthma [207].…”

Section: Introductionmentioning

confidence: 99%

Vascular Effects of Phytoestrogens and Alternative Menopausal Hormone Therapy in Cardiovascular Disease

Gencel¹,

Benjamin²,

Bahou³

et al. 2012

MRMC

119

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Phytoestrogens are estrogenic compounds of plant origin classified into different groups including isoflavones, lignans, coumestans and stilbenes. Isoflavones such as genistein and daidzein are the most studied and most potent phytoestrogens, and are found mainly in soy based foods. The effects of phytoestrogens are partly mediated via estrogen receptors (ERs): ERα, ERβ and possibly GPER. The interaction of phytoestrogens with ERs is thought to induce both genomic and non-genomic effects in many tissues including the vasculature. Some phytoestrogens such as genistein have additional non-ER-mediated effects involving signaling pathways such as tyrosine kinase. Experimental studies have shown beneficial effects of phytoestrogens on endothelial cells, vascular smooth muscle, and extracellular matrix. Phytoestrogens may also affect other pathophysiologic vascular processes such as lipid profile, angiogenesis, inflammation, tissue damage by reactive oxygen species, and these effects could delay the progression of atherosclerosis. As recent clinical trials showed no vascular benefits or even increased risk of cardiovascular disease (CVD) and CV events with conventional menopausal hormone therapy (MHT), phytoestrogens are being considered as alternatives to pharmacologic MHT. Epidemiological studies in the Far East population suggest that dietary intake of phytoestrogens may contribute to the decreased incidence of postmenopausal CVD and thromboembolic events. Also, the WHO-CARDIAC study supported that consumption of high soybean diet is associated with lower mortalities from coronary artery disease. However, as with estrogen, there has been some discrepancy between the experimental studies demonstrating the vascular benefits of phytoestrogens and the data from clinical trials. This is likely because the phytoestrogens clinical trials have been limited in many aspects including the number of participants enrolled, the clinical end points investigated, and the lack of long-term follow-up. Further investigation of the cellular mechanisms underlying the vascular effects of phytoestrogens and careful evaluation of the epidemiological evidence and clinical trials of their potential vascular benefits would put forward the use of phytoestrogens as an alternative MHT for the relief of menopausal symptoms and amelioration of postmenopausal CVD.

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Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation

Cited by 33 publications

References 31 publications

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Targeting NADPH Oxidase and Phospholipases A2 in Alzheimer’s Disease

Vascular Effects of Phytoestrogens and Alternative Menopausal Hormone Therapy in Cardiovascular Disease

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