Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet

Shen, Hsin-Hsueh; Huang, Shieh-Yang; Kung, Ching-Wen; Chen, Shuying; Chen, Yafen; Cheng, Pao-Yun; Lam, Kwok-Keung; Lee, Yen-Mei

doi:10.1016/j.jnutbio.2019.02.001

Cited by 64 publications

(38 citation statements)

References 49 publications

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“…Detection of the protein expression in the ventricular myocardium by Western blot was performed as described previously [23]. The protein concentration of the supernatant was measured by the BCA kit (Thermo Scientific, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy

Shen

Tseng

Kuo

et al. 2019

Mediators of Inflammation

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Heat stroke (HS) is a life-threatening illness and defined as when body temperature elevates above 40°C accompanied by the systemic inflammatory response syndrome that results in multiple organ dysfunctions. α-Lipoic acid (ALA) acts as a cofactor of mitochondrial enzymes and exerts anti-inflammatory and antioxidant properties in a variety of diseases. This study investigates the beneficial effects of ALA on myocardial injury and organ damage caused by experimental HS and further explores its underlying mechanism. Male Wistar rats were exposed to 42°C until their rectal core temperature reached 42.9°C and ALA was pretreared 40 or 80 mg/kg (i.v.) 1.5 h prior to heat exposure. Results showed that HS-induced lethality and hypothermia were significantly alleviated by ALA treatment that also improved plasma levels of CRE, LDH, and CPK and myocardial injury biomarkers myoglobin and troponin. In addition, ALA reduced cardiac superoxide anion formation and protein expression of cleaved caspase 3 caused by HS. Proinflammatory cytokine TNF-α and NF-κB pathways were significantly reduced by ALA treatment which may be associated with the upregulation of Hsp70. ALA significantly increased the Atg5-12 complex and LC3B II/LC3B I ratio, whereas the p62 and p-mTOR expression was attenuated in HS rats, indicating the activation of autophagy by ALA. In conclusion, ALA ameliorated the deleterious effects of HS by exerting antioxidative and anti-inflammatory capacities. Induction of Hsp70 and activation of autophagy contribute to the protective effects of ALA in HS-induced myocardial injury.

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Section: Methodsmentioning

confidence: 99%

Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy

Shen

Tseng

Kuo

et al. 2019

Mediators of Inflammation

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“…In these rodent models, isoflavones exert positive effects on body weight gain and food intake as well as in fat pats enlargement [ 297 ]. In HFD-fed ovariectomized rats the administration of genistein decreased the body weight gain, improved insulin sensitivity and reduced plasma TG and cholesterol [ 329 ]. In liver, genistein blocked the lipogenic pathway by inhibiting p-ACC, SREBP-1, FASN and CD36 proteins.…”

Section: Isoflavonesmentioning

confidence: 99%

“…In retroperitoneal WAT, genistein diminished adiposity and adipocyte hypertrophy, inflammatory phenotype and induced browning. In iWAT, genistein-supplemented rats exhibited higher levels of UCP1, PRDM16, PGC-1α and CIDEA proteins and Ppargc1a and Ucp-1 mRNAs [ 329 ]. Furthermore, isoflavones supplementation can modulate the metabolic effects of estradiol treatments in ovariectomized rats [ 330 ].…”

Section: Isoflavonesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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“…Genistein is an isoflavone compound extracted from soybeans reported to exert anticancer effects; it decreases HIF-1α levels in breast cancer cells by binding with the factor inhibiting HIF site on HIF-1α [47]. Genistein is also reported to be effective against obesity during menopause, as its administration suppresses estrogen-deficiency-induced obesity and hepatic lipogenesis by reducing NF-κB activity in an ovariectomized and high-fat diet rat model [48].…”

Section: Genisteinmentioning

confidence: 99%

Therapeutic Single Compounds for Osteoarthritis Treatment

et al. 2021

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Osteoarthritis (OA) is an age-related degenerative disease for which an effective disease-modifying therapy is not available. Natural compounds derived from plants have been traditionally used in the clinic to treat OA. Over the years, many studies have explored the treatment of OA using natural extracts. Although various active natural extracts with broad application prospects have been discovered, single compounds are more important for clinical trials than total natural extracts. Moreover, although natural extracts exhibit minimal safety issues, the cytotoxicity and function of all single compounds in a total extract remain unclear. Therefore, understanding single compounds with the ability to inhibit catabolic factor expression is essential for developing therapeutic agents for OA. This review describes effective single compounds recently obtained from natural extracts and the possibility of developing therapeutic agents against OA using these compounds.

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Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet

Cited by 64 publications

References 49 publications

Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy

Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Therapeutic Single Compounds for Osteoarthritis Treatment

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