Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice

Genistein Induces Estrogen-Like Effects in Ovariectomized Rats but Fails to Increase Cardiac GLUT4 and Oxidative Stress

“…[17][18][19][20] Furthermore, recent evidence suggests that genistein treatment reduces fat weight and fasting blood glucose and lipid levels in a mouse model of diabetes and has a positive effect on plasma lipid profiles in clinical studies and thus may help prevent obesity-associated diseases. 21,22 In addition, we recently demonstrated that genistein exerts an anti-ischemic effect in the hearts of OVX rats following a 2-day treatment period with the same concentration of genistein (250 mg=kg=day) and same route of administration (daily subcutaneous injections) as is used in the current study. 23 In view of the aforementioned previously reported protective effects of genistein on cardiovascular functions= systems, the purpose of this study was to better understand genistein's mechanism of action, more specifically in terms of its estrogen-like effects.…”

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

“…33) In the present study, it has been observed that the serum HDL-Chol level was increased significantly by feeding the isoflavones, similar results were also reported in the previous studies. 26,34) In contrast to HDL-Chol level, serum TC and TG levels did not differ by significant levels between the HF and HFISO groups. Similar study showed that soy isoflavone supplementation had no significant effect on the reduction of TG and TC levels in fasting plasma in diabetic rats.…”

“…2) Several authors reported benefits of isoflavone consumption on improvement of the serum TG and on the prevention of obesity and diabetes. 10,26) However, negative effects of isoflavones have also been reported that there are no significant effect on serum lipids, 27) plasma TG, plasma glucose, or insulin concentrations, 28) suggesting a necessity to determine the effects of isoflavones more precisely. Almost all of the experiments concerned with these reports were carried out using genistein and daidzein as aglycones, but determination of the physiological functions of daidzin and glycitin, which are isoflavone glycosides, has not yet been fully studied in C57BL/6J mice.…”

“…The CPT activity was determined from the rate of change in absorbance at 412 nm. 26) Fecal lipid analyses. Feces were collected on days 86-88 for 72 h. Total fecal lipid was extracted by the method of Folch and Lees.…”

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

“…Genistein has been shown to be a compound influencing lipid metabolism in humans and animals (Ae Park et al, 2006). However, the literature data concerning this subject are inconsistent.…”