Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells

Abstract

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Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats

“…Many studies have reported that the granule and Purkinje cells in the developing or adult cerebella are prone for apoptosis when subjected to disparate experimental conditions (Atlante et al, 2010;Iriyama et al, 2009;Norman et al, 1995;Zhang et al, 1997). All these studies reported the induction of apoptosis via mitochondrial or intrinsic pathway.…”

Role of polyphenols in cell death control

“…140 Likewise, genistein and daidzein, but not catechin and EC, have been found to prevent apoptosis in cerebella granule cells. 141 …”

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“…Recently, in CGNs undergoing apoptosis, the effect of genistein was studied at subcellular level and for the first time at mitochondrial level [110]. Genistein and to a lesser extent its analogue daidzein, both used at dietary concentrations, can prevent low potassium-dependent apoptosis in CGNs by reducing the impairment of both aerobic glucose metabolism and mitochondrial uncoupling, two processes occurring in CGN apoptosis [16].…”

“…Thus, since both genistein and daidzein have been proved to decrease ROS levels, it has been suggested that the prevention of apoptosis is essentially due to the antioxidant properties of these flavonoids [110]. Nonetheless, the effect of genistein proved to be rather specific since other flavonoids such as catechin and epicatechin failed to prevent CGN death in spite of their shared antioxidant capability.…”