Genistein protects benzotriazole ultraviolet stabilizer UV-234-induced hepatotoxicity by modulating ROS/Nrf2 and NF-κB signaling in yellow catfish (Pelteobagrus fulvidraco)

Li, Siwen; Xie, Jiaqi; Li, Xinlian; Li, Qiuyue; Tang, Xiao‐Qing; Yu, Dongke; Xiong, Xuan

doi:10.1016/j.cbpc.2023.109675

Cited by 1 publication

(2 citation statements)

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“…143 Li et al demonstrated that genistein can indirectly impede the hepatic injury induced by Benzotriazole ultraviolet stabilizers in yellow catfish (Pelteobagrus fulvidraco) through the mitigation of the NF-κB-driven inflammatory reaction. 144 Similarly, the inclusion of dietary curcumin can decrease the expression of IL-1β, IL-6, IL-8 and p65, while concurrently augmenting the non-specific immune response and antioxidant capability in grass carp. 145 Thus, use of certain mediators (such as melatonin, collagen peptides found in fish scale, haemoglobin and genistein) can induce or inhibit ROS production in fish, and subsequently regulate the antioxidant capacity and inflammation levels via the NF-κB signalling pathway.…”

Section: Ros Signalling In the Inflammatory Responsementioning

confidence: 99%

“…Notably, cypermethrin could degrade I κ B‐α in grass carp cells and accelerate the NF‐ κ B nuclear translocation to produce inflammatory cytokines, which could trigger ROS overproduction and induce hepatotoxicity 143 . Li et al demonstrated that genistein can indirectly impede the hepatic injury induced by Benzotriazole ultraviolet stabilizers in yellow catfish ( Pelteobagrus fulvidraco ) through the mitigation of the NF‐ κ B‐driven inflammatory reaction 144 . Similarly, the inclusion of dietary curcumin can decrease the expression of IL‐1β, IL‐6, IL‐8 and p65, while concurrently augmenting the non‐specific immune response and antioxidant capability in grass carp 145 .…”

Section: Role Of Ros In the Inflammatory Signalling Pathway In Fishmentioning

confidence: 99%

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Signalling regulation of reactive oxygen species in fish inflammation

Gao,

Zhao,

Shi

et al. 2024

Reviews in Aquaculture

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Reactive oxygen species (ROS), which are key cellular signalling molecules, are reactive chemicals containing oxygen. Cell survival or death is a critical issue in the inflammatory response. Accumulation of ROS involves ROS generation and scavenging, which determine ROS homeostasis. Understanding the roles of ROS in modulating the inflammatory response in fish is vital for helping protect fish from the damage of water pollutants in harsh environmental conditions. ROS‐related key genes and signalling pathways are relatively conserved in fish but vary among different species. Recent frequent incidences of fish diseases have posed a considerable challenge to large‐scale aquaculture. ROS is important in stress perception, integration of diverse stress‐responsive signalling networks, and activation of animal defence mechanisms, which frequently occur during inflammation in fish. This review summarises recent studies on ROS signalling pathways during inflammation in fish. Furthermore, it examines the relationship between ROS and inflammation in fish. This review may contribute to the understanding of the underlying mechanisms by which ROS regulate inflammation in fish and provide suggestions for sustainable development in aquaculture.

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Section: Ros Signalling In the Inflammatory Responsementioning

confidence: 99%