2012
DOI: 10.1016/j.nutres.2012.10.002
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Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats

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Cited by 40 publications
(37 citation statements)
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“…A few studies have evaluated the association of phytoestrogens and hepatic steatosis in estrogen-deficient animals. Genistein increases the rate of b-oxidation through increasing the activity of succinate dehydrogenase and CPT-1 in OVX rats (Choi et al 2012). However, in postmenopausal women, 12-week consumption of elderberry extracts rich in anthocyanins (500 mg/day) did not change biomarkers of liver function, although the plasma concentrations of anthocyanin metabolites of the elderberry treatment group were greater (P = 0.02) than that of the control at week 12 of the treatment (Curtis et al 2009).…”
Section: Discussionmentioning
confidence: 88%
“…A few studies have evaluated the association of phytoestrogens and hepatic steatosis in estrogen-deficient animals. Genistein increases the rate of b-oxidation through increasing the activity of succinate dehydrogenase and CPT-1 in OVX rats (Choi et al 2012). However, in postmenopausal women, 12-week consumption of elderberry extracts rich in anthocyanins (500 mg/day) did not change biomarkers of liver function, although the plasma concentrations of anthocyanin metabolites of the elderberry treatment group were greater (P = 0.02) than that of the control at week 12 of the treatment (Curtis et al 2009).…”
Section: Discussionmentioning
confidence: 88%
“…Ovariectomy (OVX) in rodent is considered to resemble human menopause. OVX results in increase of fat mass [2], [3] and chronic inflammation accompanied by IR [4], [5], [6], [7], implying a connection between metabolic complications observed in OVX and obesity. Chronic inflammation, which simultaneously occurs in obesity, contributes to IR and T2D [8].…”
Section: Introductionmentioning
confidence: 99%
“…43 Various phytoestrogens prevented higher risk levels for obesity or vaginal atrophy in OVX murine models. 44,45 In this study, Cys partially improved body overweightness and vaginal atrophy. In addition, Cys increased the serum E 2 level in OVX mice.…”
Section: Discussionmentioning
confidence: 49%