Genital Darier’s Disease: A Case Report

Abstract

Introduction: Darier's in the gentital tract is an uncommon hereditary disease. Its clinical manifestation on the vulva is rare. Case Presentation: A 59 year old woman with dyspareunia and pruritus with verrocus papules on labia minor and major. Pap smear of cervix showed a low grade squamous intraepithelial lesion, but during a biopsy it was found to be vaginal involvement by Darier's disease. Conclusions: Some skin diseases such as Darier may involve vaginal tract and cervix and diagnosis need special consideration by biopsy.

Diagnosis and management of vulvar Darier disease: A case report

“…They act by suppressing acantholysis and dyskeratosis; they also induce cell proliferation, keratinization, and immunomodulation, resulting in relief of the symptoms. Mansouri et al reported a case of a woman with hyperkeratotic papules on the vulva [ 15 ]. A skin biopsy was performed for the diagnosis, and the pathology report was consistent with Darier disease.…”