Genital gender-affirming surgery for transgender women

Sluis, Wouter B. van der; Schäfer, Tim; Nijhuis, T.; Bouman, Mark‐Bram

doi:10.1016/j.bpobgyn.2022.102297

Cited by 16 publications

(6 citation statements)

References 47 publications

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“…Segundo diversos autores (SLUIS et al;2023;WATANABE et al, 2022;HASSAN;SUN;JHA, 2021;LI;CRANE;SANTUCCI., 2021;GENTIL et al, 2020), a vaginoplastia de inversão peniana é o padrão ouro e procedimento mais realizado, no qual a neovagina é revestida com um retalho cutâneo peniano invertido pediculado, podendo ser aumentado mediante enxertos de pele oriundos do escroto. A partir da utilização desta técnica, relatou-se complicações como lesão retal intra operatória, fístulas retovaginais, estenose neovaginal e cicatriz na maioria dos pacientes.…”

Section: Discussionunclassified

Gender-affirming surgical procedures and their psychosocial impacts: an integrative review

Moreira Ramos,

Melo,

Rolim

et al. 2024

CLIUM

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Objective: Identify the main gender affirmation surgery techniques related to the construction of a neovagina and a neopenis and the consequent impact of these procedures on the mental issues of transgender people. Methods: This is an integrative literature review with an electronic survey of articles selected between August and September 2023, using MEDLINE (International Literature in Health Sciences) and LILACS (Latin American and Caribbean Literature in Health Sciences) via the Virtual Health Library (VHL) portal and PubMed (U.S. National Library of Medicine), portraying the main surgical procedures for gender reassignment and their psychosocial impacts on the transsexual community. Results: 21 articles were obtained that made up the final sample of the present study. Final considerations: Studies point to the satisfaction of transgender individuals after gender affirmation surgeries and consequent improvement in the mental health of this community despite the lack of standardization in measurement methods related to quality of life aspects, which impacts and limits the comparison between Works.

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Section: Discussionunclassified

Gender-affirming surgical procedures and their psychosocial impacts: an integrative review

Moreira Ramos,

Melo,

Rolim

et al. 2024

CLIUM

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“…Trans women may undergo GAHT which usually combines the administration of estrogens and anti-androgens to suppress endogenous testosterone production and to develop feminine secondary sexual characteristics (Hembree et al ., 2017; Coleman et al ., 2022). Following feminizing GAHT, trans women without any surgical contraindications can opt for a sex reassignment surgery (SRS) which typically consists of a bilateral orchidectomy, as well as a gender-affirming vulvoplasty or vaginoplasty (van der Sluis et al ., 2023).…”

Section: Introductionmentioning

confidence: 99%

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

Delgouffe,

Silva,

Chalmel

et al. 2024

Preprint

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Although the impact of gender-affirming hormone therapy (GAHT) on spermatogenesis in trans women has already been studied, data on its precise effects on the testicular environment is poor. Therefore, this study aimed to characterize, through histological and transcriptomic analysis, the spermatogonial stem cell niche of 106 trans women who underwent standardized GAHT, comprising estrogens and cyproterone acetate. A partial dedifferentiation of Sertoli cells was observed, marked by the co-expression of androgen receptor and anti-Müllerian hormone which mirrors the situation in peripubertal boys. The Leydig cells also exhibited a distribution analogous to peripubertal tissue, accompanied by a reduced insulin-like factor 3 expression. Although most peritubular myoid cells expressed alpha-smooth muscle actin 2, the expression pattern was disturbed. Besides this, fibrosis was particularly evident in the tubular wall and the lumen was collapsing in most participants. A spermatogenic arrest was also observed in all participants. The transcriptomic profile of transgender tissue confirmed a partial rejuvenation and, in addition, detected inflammation processes occurring in the samples. The present study shows that GAHT changes the spermatogonial stem cell niche by partially rejuvenating the somatic cells and inducing fibrotic processes. These findings are important to further understand how estrogens and testosterone suppression affect the testis environment, and in the case of orchidectomized testes as medical waste material, their potential use in research.

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“…It is worth noting that >75% of trans women express a desire for gender-affirming genital surgery [5] .…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Neovaginal Prolapse After Vaginoplasty in Trans Women

Tran,

Guillot-Tantay,

Sabbagh

et al. 2024

European Urology Open Science

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Genital gender-affirming surgery for transgender women

Cited by 16 publications

References 47 publications

Gender-affirming surgical procedures and their psychosocial impacts: an integrative review

Gender-affirming surgical procedures and their psychosocial impacts: an integrative review

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

Systematic Review of Neovaginal Prolapse After Vaginoplasty in Trans Women

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