Introduction: Syphilis is one of the oldest sexually transmitted diseases caused by the bacterium Treponema pallidum. It is characterized by multiple clinical presentations and a long duration. Acquired syphilis is divided into early (≤ 1 year after infection) and late (> 1 year after infection) stages. Venereal diseases, more often defined as sexually transmitted diseases (STDs), result from behaviours influenced by socio-economic, psychological, and cultural factors. Although the spectrum of sexually transmitted diseases, apart from classic syphilis and gonorrhoea, encompasses a wide range of aerobic and anaerobic bacteria, viruses, protozoans, fungi, and even insects, the frequency of late syphilis has been on the rise in recent years. It is a significant clinical problem in our country. Irrespective of the COVID SARS-19 pandemic, this is an important issue of contemporary epidemiology.