Genital tract microbial isolate in women with preterm pre-labour rupture of membranes in resource-constrained community setting

Eleje, George Uchenna; Adinma, J. I. B.; Ugwuanyi, Daniel C.; Ikechebelu, Joseph Ifeanyichukwu; Okafor, CI; Ezeama, Chukwuemeka Okwudili; Ogbuagu, Chukwuanugo Nkemakonam

doi:10.3109/01443615.2014.970145

Cited by 8 publications

(18 citation statements)

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“…[ 15 23 24 ] Some studies have shown that infection with GBS might release cytokines and other inflammatory modulators which could cause membrane rupture. [ 23 25 ] This study found an association between PPROM and GBS. In this study, the prevalence rates of GBS in the women with PPROM ranged from 4.2% to 22.3%, similar with the results of other studies.…”

Section: Discussionmentioning

confidence: 71%

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes

Zhang

Sun

Zhu

et al. 2017

Chinese Medical Journal

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Background:Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of infections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM.Methods:In training group, the 112 pregnant women with PPROM were enrolled in the case subgroup, and 108 normal pregnant women in the control subgroup using an unmatched case-control method. The sociodemographic characteristics of these participants were collected by face-to-face interviews. Vaginal excretions from each participant were sampled at 28–36+6 weeks of pregnancy using a sterile swab. DNA corresponding to Chlamydia trachomatis (CT), Ureaplasma urealyticum (UU), Candida albicans, group B streptococci (GBS), herpes simplex virus-1 (HSV-1), and HSV-2 were detected in each participant by real-time polymerase chain reaction. A model of Bayesian discriminant analysis was established and then verified by a multicenter validation group that included 500 participants in the case subgroup and 500 participants in the control subgroup from five different hospitals in the Shaanxi province, respectively.Results:The sociological characteristics were not significantly different between the case and control subgroups in both training and validation groups (all P > 0.05). In training group, the infection rates of UU (11.6% vs. 3.7%), CT (17.0% vs. 5.6%), and GBS (22.3% vs. 6.5%) showed statistically different between the case and control subgroups (all P < 0.05), log-transformed quantification of UU, CT, GBS, and HSV-2 showed statistically different between the case and control subgroups (P < 0.05). All etiological agents were introduced into the Bayesian stepwise discriminant model showed that UU, CT, and GBS infections were the main contributors to PPROM, with coefficients of 0.441, 3.347, and 4.126, respectively. The accuracy rates of the Bayesian stepwise discriminant analysis between the case and control subgroup were 84.1% and 86.8% in the training and validation groups, respectively.Conclusions:This study established a Bayesian stepwise discriminant model to predict the incidence of PPROM. The UU, CT, and GBS infections were discriminant factors for PPROM according to a Bayesian stepwise discriminant analysis. This model could provide a new method for the early predicting of PPROM in pregnant women.

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Section: Discussionmentioning

confidence: 71%

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes

Zhang

Sun

Zhu

et al. 2017

Chinese Medical Journal

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“…Two of these studies reported PPROM. 6,27 Pregnant women with trichomoniasis had 1.87 times the odds of PROM compared with uninfected women (OR 1.87; 95% CI 1.53-2.29) (Figure 2). Heterogeneity among studies was low (Cochran's Q test P = 0.28; I 2 = 19%).…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

“…Among the studies included in this meta-analysis, nine did not report how estimated gestational age was determined. 6,8,22,[25][26][27]47,50,51 Those that did report this used either the mother's last menstrual period, ultrasound or a combination of the two (Table S1).…”

Section: Quality Assessment and Risk Of Bias Within Studiesmentioning

confidence: 99%

Trichomoniasis and adverse birth outcomes: a systematic review and meta‐analysis

Gerwen

Craig-Kuhn

Jones

et al. 2021

BJOG

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Background Trichomoniasis commonly affects women of childbearing age and has been linked to several adverse birth outcomes.Objective To elucidate the association between trichomoniasis in pregnant women and adverse birth outcomes, including preterm delivery, prelabour rupture of membranes and low birthweight.Search strategy MEDLINE, EMBASE and ClinicalTrials.gov were systematically searched in December 2020 without time or language restrictions.Selection criteria Original research studies were included if they assessed at least one of the specified adverse birth outcomes in pregnant women with laboratory-diagnosed trichomoniasis.Data collection and analysis Estimates from included articles were either extracted or calculated and then pooled to produce a combined estimate of the association of trichomoniasis with each adverse birth outcome using the random effects model. Heterogeneity was assessed using the I 2 statistic and Cochran's Q test.Main results Literature search produced 1658 publications after removal of duplicates (n = 770), with five additional publications identified by hand search. After screening titles and abstracts for relevance, full text of 84 studies was reviewed and 19 met inclusion criteria for meta-analysis. Significant associations were found between trichomoniasis and preterm delivery (OR 1.27; 95% CI 1.08-1.50), prelabour rupture of membranes (OR 1.87; 95% CI 1.53-2.29) and low birthweight (OR 2.12; 95% CI 1.15-3.91).Conclusions Trichomoniasis in pregnant women is associated with preterm delivery, prelabour rupture of membranes and low birthweight. Rigorous studies are needed to determine the impact of universal trichomoniasis screening and treatment during pregnancy on reducing perinatal morbidity.

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“…AmnioQuick Duo+ also identified women with PROM who did not go on to deliver within the next 7 days. This might help to circumvent the substantial costs associated with unnecessary hospitalization, the maternal risks associated with prolonged antibiotics, and the fetal risks associated with steroid therapy …”

Section: Discussionmentioning

confidence: 99%

“…This might help to circumvent the substantial costs associated with unnecessary hospitalization, the maternal risks associated with prolonged antibiotics, and the fetal risks associated with steroid therapy. 24,25 The main strengths of the present study are its double-blind design and strictly defined inclusion criteria. To the best of our knowledge, no other study has reported the diagnostic indices of AmnioQuick Duo+ as compared with PAMG-1 for the exclusive diagnosis of prolonged PROM.…”

Section: Discussionmentioning

confidence: 99%

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Eleje

Ezugwu

Ezebialu

et al. 2018

Intl J Gynecology & Obste

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Objective To compare AmnioQuick Duo+ versus the placental α‐microglobulin‐1 (PAMG‐1) test for diagnosis of prolonged premature rupture of membranes (PROM). Methods A multicenter prospective cohort study included women with suspected PROM at six tertiary institutions in southern Nigeria between January 1 and December 31, 2015. The inclusion criteria were features of PROM lasting at least 24 hours and a pregnancy duration of more than 24 weeks. AmnioQuick Duo+ (Biosynex, Strasbourg, France) and PAMG‐1 (AmniSure International, Boston, USA) tests were used to diagnose PROM, which was confirmed after delivery by any two of the following criteria: delivery within 48 hours to 7 days, chorioamnionitis, membranes perceptibly ruptured at delivery, and adverse perinatal outcomes considerably associated with prolonged PROM. Results Of 100 women assessed for eligibility, 99 were included. Sensitivity, specificity, and accuracy were, respectively, 97.3%, 100%, and 95.9% for AmnioQuick Duo+, and 93.2%, 100%, and 90.4% for PAMG‐1. The differences were not significant and the diagnostic discordant rate between the two tests was 3.1%. In equivocal cases (i.e., negative pooling test result), AmnioQuick Duo+ and PAMG‐1 performed equally (diagnostic accuracy, 100% vs 97.7%; P>0.99). Conclusion For diagnosis of PROM, AmnioQuick Duo+ was found to be non‐inferior and comparable in accuracy to the PAMG‐1 test, with a diagnostic discordance rate of 3.1%.

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Genital tract microbial isolate in women with preterm pre-labour rupture of membranes in resource-constrained community setting

Cited by 8 publications

References 15 publications

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes

Trichomoniasis and adverse birth outcomes: a systematic review and meta‐analysis

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

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