Genital ulcer disease and human immunodeficiency virus: a focus

Sardana, Kabir; Sehgal, Virendra

doi:10.1111/j.1365-4632.2005.02268.x

Cited by 4 publications

(4 citation statements)

References 102 publications

(230 reference statements)

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“…In our study, the lesions of herpes were larger, extensive, deeper, and more necrotic in the seropositive group when compared to the seronegative group as supported by earlier studies 6,8,23,24 ( Figure 1). There have been numerous case reports highlighting the atypical presentation of herpes in seropositive patients such as chronic perianal ulcerative lesions, exuberant, hypertrophic, condyloma-like, tumor-like nodules, and vegetative plaque-type lesions.…”

Section: Morphological Differences In the Clinical Presentation Of Stsupporting

confidence: 89%

“…Increased risk of acyclovir resistance in seropositive patients has also been well reported in the literature. 6,8,12,27,[30][31][32] This has clinical implications as recent studies have shown that the risk of seroconversion in HIV-discordant couples is more in patients with genital herpes, thereby stressing the need for effective alternative treatment modalities such as cidofovir, imiquimod, and foscarnet in seropositive patients. 7,16 Growths: Genital Warts Genital warts occur with increased frequency in seropositive patients, especially in men who have sex with men (MSMs) and with decreasing CD4 counts.…”

Section: Morphological Differences In the Clinical Presentation Of Stmentioning

confidence: 99%

“…1,2 This mutual interaction between HIV and STD can profoundly affect the transmission dynamics of HIV. [3][4][5][6][7][8] These STDs present with atypical clinical manifestations in seropositive patients with extensive, persistent involvement, altered morphology, and coexistence of multiple sexually transmitted infections (STIs). [1][2][3]5,6,8 In countries like India, where there is high prevalence of STIs, targeted STD detection and treatment especially in seropositive patients may have a central role in reducing HIV burden as suggested by randomized controlled intervention trials.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8] These STDs present with atypical clinical manifestations in seropositive patients with extensive, persistent involvement, altered morphology, and coexistence of multiple sexually transmitted infections (STIs). [1][2][3]5,6,8 In countries like India, where there is high prevalence of STIs, targeted STD detection and treatment especially in seropositive patients may have a central role in reducing HIV burden as suggested by randomized controlled intervention trials. 2,5,7,9 The current program, National AIDS Control Programme-IV (NACP-IV), 2012 to 2017, aims to reduce annual new HIV infections by 50% through targeted interventions for key affected groups with high risk of transmission (patients with STI).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinico-Epidemiological Profile of Viral Sexually Transmitted Infections in Seropositive Patients Attending a Tertiary Care Hospital in North India

Chugh

Garg

Sarkar

et al. 2017

J Int Assoc Provid AIDS Care

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Sexually transmitted diseases are a major public health problem both in developing and in developed countries, and especially with the co-synergy with HIV infection, there is an increasing need to have a proper understanding of the clinicodemographic patterns of sexually transmitted infections (STIs) for planning and implementing control strategies. Worldwide, there is an increased preponderance of viral STIs. Increasing incidence and altered clinical presentation of viral STIs in patients with HIV pose a diagnostic challenge; thereby, we studied the demographic profile of HIV-seropositive patients and compared clinical manifestations of viral STIs in HIV-seropositive patients to those in seronegative individuals. Twenty-seven HIV-seropositive patients with viral STI (herpes/molluscum/warts) and same number of age-, sex-, and STI-matched seronegative patients were studied for variability in clinical profile. There were significant differences in the demographic factors (education, income, and migration) and sexual practices (number of contacts and source of infection) in the 2 groups. Lesional symptoms, increased extent of lesions, and resistance to treatment were significantly more common in HIV-seropositive patients.

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Section: Morphological Differences In the Clinical Presentation Of Stsupporting

confidence: 89%