Genital Yeast Infections

Oriel, J D; Partridge, Betty M.; Denny, Maire J.; Coleman, Janice

doi:10.1136/bmj.4.5843.761

Cited by 162 publications

(61 citation statements)

References 14 publications

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“…10 C. glabrata frequency was the highest (69.4%) of the four Candida species. Isolation rate of C. glabrata are similar to those of Oriel et al and Consolaro et al 11,12 It is normal for asymptomatic women to have a high isolation rate of non-albicans yeast. This is explained by the fact that the symptoms of non-albicans are much less than the symptoms of albicans.…”

Section: Discussionsupporting

confidence: 83%

Antifungal susceptibilities and identification of Candida species by using maldi-tof microbial identification system from cervicovaginal samples

Erbaş¹,

Parın²,

Kırkan³

et al. 2017

Int J Res Med Sci

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Background: Among the vaginal diseases seen in women, candidiasis is in the first place. This disease, which is caused by Candida species, can sometimes persist very stubbornly. The aim of this study was to determine Candida species isolated from vaginal specimens by using VITEK MS (MALDI-TOF Microbial Identification System) rapid identification system and to evaluate their susceptibility to some antifungals.Methods: In this study, 220 cervicovaginal swab were used. Isolates were identified by VITEK MS rapid identification system. After identification, antifungal susceptibility testing was performed using the M-44 A2 guideline of The Clinical and Laboratory Standards Institute (CLSI).Results: Total 16.3% (36) of Candida spp. positivity was determined from 220 cervicovaginal samples, and 25 (69.4%) C. glabrata, 6 (16.7%) C. albicans, 3 (8.3%) C. kefyr and 2 (5.6%) C. krusei were obtained with Vitek MS. All identified C. albicans strains were found to be completely resistant to all antifungals used except nystatin agent, C. krusei strains were found to be resistant to flucytosine but sensitive to all other antifungals, C. glabrata and C. kefyr strains were susceptible to all antifungals within the antifungals used in this study.Conclusions: It is concluded that it is necessary to distinguish Candida species in order to apply a correct treatment. And species selection is very important for the selection of antifungal to be used. Nystatin is recommended if no laboratory tests are to be performed for the diagnosis of Vaginal Candidiasis.

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Section: Discussionsupporting

confidence: 83%

Antifungal susceptibilities and identification of Candida species by using maldi-tof microbial identification system from cervicovaginal samples

Erbaş¹,

Parın²,

Kırkan³

et al. 2017

Int J Res Med Sci

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“…For diagnosis at least 3 out of 4, Amsel [2] criteria should be present for diagnosis which includes: (1) Homogenous gray or white adherent discharge on the vaginal wall, (2) Vaginal pH [ 4.5, (3) Positive whiff test and (4) Presence of clue cells on microscopic examination of saline wet mount or gram stain of vaginal discharge [3]. Vaginal candidiasis caused by Candida Albicans, Candida Parapsilosis, Candida Tropicalis or Candida Glabrata [4]. Vaginal trichomoniasis caused by Trichomonas Vaginalis.…”

Section: Introductionmentioning

confidence: 99%

Study to Evaluate Targeted Management and Syndromic Management in Women Presenting with Abnormal Vaginal Discharge

Meena

2016

J Obstet Gynecol India

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Introduction Vaginal discharge is a commonest complaint among women in reproductive age group. Infective vaginal discharge can be broadly categorized into vaginitis or mucopurulent cervicitis. Vaginitis is predominantly caused by bacterial vaginosis, vaginal candidiasis, vaginal trichomoniasis, etc. Mucopurulent cervicitis is due to chlamydia or gonococcal infection. The targeted management is based on identification of causative organism and targeting the therapy against it, while syndromic management is based on high risk factors's presence. Aims and Objectives To study the effect of targeted management as compared to syndromic management in achieving a complete cure for abnormal vaginal discharge and to study the microbial flora of women presenting with abnormal vaginal discharge. Method The study is a randomized control trial conducted at tertiary health care on 200 women who presented with abnormal vaginal discharge, distributed in two groups A and B each consisted of 100 women. Group A underwent laboratory investigations, and treatment was started as soon as reports were available. Group B was given syndromic management based on high risk factors's presence. Both groups were followed up after 2 weeks. 123Results The prevalence of various organisms in vaginal discharge was candidiasis 39 %, bacterial vaginosis 28 %, trichomoniasis 5 %, N. gonorrhoeae 5 % and chlamydia 2 % among the 100 women in group A. Response to treatment for vaginitis was 76.3 % in group A, whereas it was 41 % in group B. With cervicitis, 71.4 % women responded to treatment in targeted group as compared to 54 % in syndromic management group. Conclusion There is a potential disadvantage of syndromic management because of its total reliability on a subjective clinical assessment.

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“…Other evidence has focused on epididymitis, which in young men is often attributable to C trachomatis (Eley et al, 1992). Epididymitis is thought to be important because fertility might be affected due to inflammation and obstruction, especially where both testes are affected (Oriel and Ridgway, 1983). As well as creating a physical blockage to the movement of sperm, C trachomatis can also cause epithelial damage that reduces spermatogenesis, induces immunological responses that destroy or hinder sperm, and reduces the female partner's fertility (Gonzalez et al, 2004).…”

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confidence: 99%

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Kokab

Akhondi

Sadeghi

et al. 2010

Journal of Andrology

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The aim of this study was to determine whether interleukin (IL)-6 and IL-8 concentrations, as well as numbers of seminal leukocytes in a population of infertile men, some of whom were Chlamydia trachomatis positive, were related to chlamydial infection. Our patient group included 255 men attending for diagnostic semen analysis as part of infertility investigations. Significantly raised levels of IL-8, but not IL-6, were found in C trachomatis-infected patients but not in uninfected patients. Raised IL-8 levels in semen were also associated with an increase in semen volume. There was a relationship between C trachomatis infection and lower progressive motile sperm, as well as an increase in seminal leukocytes. The overall prevalence rate for C trachomatis was 6.2%, and more infections were detected in semen than in first void urine. This study supports the suggestion that IL-8 might be used as a marker for male genital tract infection, especially when due to C trachomatis. In this study, there was a relationship between the presence of C trachomatis in semen and alterations of some semen parameters. Further investigations should be performed to understand the disparities of first void urine and semen testing for detection of C trachomatis in males.

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Genital Yeast Infections

Cited by 162 publications

References 14 publications

Antifungal susceptibilities and identification of Candida species by using maldi-tof microbial identification system from cervicovaginal samples

Antifungal susceptibilities and identification of Candida species by using maldi-tof microbial identification system from cervicovaginal samples

Study to Evaluate Targeted Management and Syndromic Management in Women Presenting with Abnormal Vaginal Discharge

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

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