Genkwanin and iridoid glycosides from Leonurus turkestanicus

Isaev, I. M.; Агзамова, М. А.; Исаев, М. И.

doi:10.1007/s10600-011-9857-9

Cited by 24 publications

(8 citation statements)

References 5 publications

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“…[18-21] However, there are some problems in these methods, such as tedious, time consuming, and multiple step developments and high capital requirement. Since genkwanin is a low polarity flavonoid and has poor solubility in the solvent system of water-methanol, HPLC has a problem of long retention and low sample recovery.…”

Section: Introductionmentioning

confidence: 99%

STUDIES ON A SIMPLE AND EFFICIENT METHOD FOR LARGE-SCALE PREPARATION OF GENKWANIN FROM DAPHNE GENKWA SIEB. ET ZUCC. USING NORMAL-PHASE FLASH CHROMATOGRAPHY

Shu

Liang

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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Genkwanin, a flavonoid which has anti-oxidant and anti-tumor activities, was isolated and purified from flowers of Daphne genkwa Sieb. et Zucc. in a large-scale by normal-phase flash chromatography (NPFC). Dried flower buds were extracted with methanol at room temperature and concentrated. The residues were suspended in water and first extracted with petroleum ether, and then chloroform. Genkwanin was concentrated in the chloroform and insoluble fractions. Under the target-guidance of thin layer chromatography (TLC) as well as solubility, a solvent system composed of cyclohexane-acetone (22:3, v/v) was selected. At a flow rate of 30 mL/min,the insoluble and chloroform fractions were separated to yield 1.5 g and 1.35 g of genkwanin with high purities of 98.3% and 98.6% by HPLC analysis, respectively. The chemical structure of the compound was identified by ESI-MS and NMR. Results of the present study indicated that NPFC was a large preparative-scale, speedy and simple process separation technology and it was feasible to find the appropriate proportion of solvent system by transformation from TLC condition.

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Section: Introductionmentioning

confidence: 99%

STUDIES ON A SIMPLE AND EFFICIENT METHOD FOR LARGE-SCALE PREPARATION OF GENKWANIN FROM DAPHNE GENKWA SIEB. ET ZUCC. USING NORMAL-PHASE FLASH CHROMATOGRAPHY

Shu

Liang

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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“…Interpretation of the 1 H– 1 H COSY correlations (Figs and S4) permitted the establishment of spin systems corresponding to the H‐1/H‐2/H‐3, H‐5/H‐6/H‐7/H‐8, H‐15/H‐16/H‐17, H‐22/H‐23/H‐24, and H‐11/H12 portions of 1 . The 1 H and 13 C NMR spectroscopic data of 1 confirmed that the compound was a cycloartane triterpene monoxyloside and was highly similar to those of cycloalpioside d with the differences that an extra hydroxyl group was attached at C‐15 in 1 . Compared with cycloalpioside d , the C‐15 ( δ C 88.0) signal was apparently deshielding, shifted by 39.2 p.p.m., showing the existence of the hydroxyl group at C‐15 in 1 .…”

Section: Resultsmentioning

confidence: 72%

Structure elucidation of a new cycloartane triterpene glycoside from Souliea vaginata by NMR

Zhu

Sun

et al. 2016

Magnetic Reson in Chemistry

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“…The chromatographic separation of the plant extracts and the spectral analysis of the separated compounds revealed the identification of the triterpenoids lupyl acetate [20] and was previously isolated from the same plant species [13] and lupeol [21]) that was isolated before from E. conyzoides [13], The monoterperpenoidal 5-methylcoumarins ethuliacoumarin (1) which was isolated previously from the same plant species by Baldaa et al, (1980) and [8,9], isoethyliacoumarin A (2) and isoethuliacoumarin C (3) which were isolated previously from the same plant species by (Baldaa et al, 1980) [8], as well as the flavonoid 7-O-methyl apigenin (Genkwanin) [22], which has not been isolated previously from E. conyzoides.…”

Section: Resultsmentioning

confidence: 99%

Acaricidal Activity of Ethulia conyzoides Extracts and Constituents against Tetranychus urticae Koch

Dawidar¹,

Abdel-Mogib²,

El-Naggar³

et al. 2015

IJSEA

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Abstract:The acaricidal potential of Ethulia conyzoides L. aerial parts extracts as well as its isolated compounds were investigated against larvae and adults of Tetranychus urticae Koch under laboratory conditions. Chromatographic separation of the extracts gave 3-O-acetyl lupeol, lupan-3-ol, ethuliacoumarin (1) and 7-O-methyl apigenin (Genkwanin), besides a mixture of isoethyliacoumarin A (2), isoethuliacoumarin C (3). The biological evaluation results indicated that ethyl acetate fraction and ethuliacoumarin (1) were the most potent to larvae and adults of Tetranychus urticae. The LC50 values of ethyl acetate fraction were found to be 11.58 and 17.86 ppm, respectively and LC50 values of (1) were found to be 12.72 and 19.22 ppm, respectively after 7 days of treatment.

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Genkwanin and iridoid glycosides from Leonurus turkestanicus

Cited by 24 publications

References 5 publications

STUDIES ON A SIMPLE AND EFFICIENT METHOD FOR LARGE-SCALE PREPARATION OF GENKWANIN FROM DAPHNE GENKWA SIEB. ET ZUCC. USING NORMAL-PHASE FLASH CHROMATOGRAPHY

STUDIES ON A SIMPLE AND EFFICIENT METHOD FOR LARGE-SCALE PREPARATION OF GENKWANIN FROM DAPHNE GENKWA SIEB. ET ZUCC. USING NORMAL-PHASE FLASH CHROMATOGRAPHY

Structure elucidation of a new cycloartane triterpene glycoside from Souliea vaginata by NMR

Acaricidal Activity of Ethulia conyzoides Extracts and Constituents against Tetranychus urticae Koch

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