Geno- and cytotoxicity induced on Cyprinus carpio by aluminum, iron, mercury and mixture thereof

Gómez-Oliván, Leobardo Manuel; Mendoza-Zenil, Youssef Paolo; SanJuan-Reyes, Nely; Galár-Martínez, Marcela; Ramírez-Durán, Ninfa; Martín-Doimeadios, Rosa del Carmen Rodríguez; Fariñas, Nuria Rodríguez; Islas-Flores, Hariz; Elizalde-Velázquez, Armando; García-Medina, Sandra; Pérez-Pastén-Borja, Ricardo

doi:10.1016/j.ecoenv.2016.09.037

Cited by 20 publications

(8 citation statements)

References 85 publications

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“…Diverse studies have shown that exposure to high concentrations of Al can trigger a wide range of toxicity mechanisms in different animal models (Martínez-vieyra et al, 2017;Mathiyazahan et al, 2015;Ward et al, 2006). In aquatic organisms environmental exposure to Al has been related to embryolethality and teratogenic effects (Kovrižnych et al, 2013;Monaco et al, 2017), neurotoxicity (Monaco et al, 2017), geno-cytotoxicity and congenital malformations (Gómez-Oliván et al, 2017;Quiroga-Santos et al, 2021), morphological and behavioral alterations (Grassie et al, 2013;Griffitt et al, 2008) , iono and osmo regulatory disturbances (Kumar and Gill, 2014) and oxidative stress (González-González et al, 2014;Razo-Estrada et al, 2013).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio

Sánchez-Aceves

Pérez-Álvarez

Gómez-Oliván

et al. 2021

Comparative Biochemistry and Physiology Part C: Toxicology &

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio

Sánchez-Aceves

Pérez-Álvarez

Gómez-Oliván

et al. 2021

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Many studies have reported synergistic effects from the combination of toxicants. For example, the combination of Al and Hg as well as the combination of As and Pb have been shown to result in synergistic effects (Pohl et al 2011, Gómez-Oliván et al 2016). As such, the issue of multiple exposures and how they could possibly influence gender-specificity is another limitation of this current examination.…”

Section: Study Limitationsmentioning

confidence: 99%

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

Kern¹,

Homme

King³

et al. 2017

Acta Neurobiologiae Experimentalis

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The prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention-deficit/hyperactivity disorder, tic disorder, obsessive-compulsive disorder, and emotional disturbances, has increased notably in the past few decades.To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. One consistent aspect of NDs is the male preponderance. This review considers the issue of male preponderance by reviewing the gender-specific neurotoxic effects of recognized neurotoxicant chemicals to assess their possible etiology in NDs. This investigation consisted of a systematic literature review of original studies published from 1970-2016 on suspected neurotoxicants, to examine whether they have a disproportionate adverse effect based on gender. Based on that review, the neurotoxicants exhibiting consistent gender-specific effects, with exposed males being more affected (than similarly exposed females), were: lead, Thimerosal/ethylmercury, some organochlorine pesticides (e.g., dieldrin, endosulfan, and heptachlor), and air pollution. The next group identified were neurotoxicants exhibiting gender-specific neurotoxic effects, with males being somewhat (but not consistently) more affected than females: mercury vapor, polychlorinated biphenyls (PCBs), and organophosphate pesticides. Finally, there was a group of studies in which the neurotoxicants exhibited apparent gender-related neurotoxic effects but failed to show whether exposed males were consistently more affected than females: inorganic mercury salts, methylmercury species, and certain endocrine disruptors (e.g., phthalates and BPA). The overall conclusion from the studies reviewed was that the brain in males is more vulnerable to many toxic exposures than it is in females. Evidence suggests that the reasons for the male brain being more vulnerable include:(1) greater glutathione availability in females; (2) greater sulfate-based detoxification capacity in females; (3) potentiating effects of co-exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress.

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“…Дефекти ERCC1залежної активності призводять до геномної нестабільності та знижують життєздатність клітин. Генотоксичність впливу ртуті була продемонстрована в клітинах крові звичайного коропа (Gómez-Oliván et al, 2017). Однак вплив неорганічної ртуті на системи відновлення ДНК у мозку риб досі не були представлені у літературі.…”

Section: результати та їх обговоренняunclassified

Indices of the DNA repair system in the brain of fish as a biomarker of inorganic mercury burden

Nedzvetsky

Gasso

Novitskyi

et al. 2021

ean

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Mercury is a widespread heavy metal that causes a stable and prolonged environmental pollution. Low concentrations of inorganic and organic mercury compounds are found in almost all water bodies. The high level of mercury bioaccumulation is a cause of tissue-specific toxicity, including neurotoxicity. Absorbed in nervous tissue mercury can cause brain disorders both in neural and glial cells. The brain of fish is considered one of the most susceptible targets for cytotoxicity of mercury in aquatic ecosystems. Taking into account that different forms of mercury have widespread distribution and exhibit a strong neurotoxic effect, the assessment of mercury cytotoxicity in the brain of fish is relevant and extremely important. Rainbow trout Oncorhynchus mykiss was exposed to mercury chloride in the dose range of 5-20 μg/L for 60 days to study the chronic exposure of low doses. In this paper, we studied the influence of inorganic mercury on oxidative stress, DNA repair proteins – ERCC1 and PARP1 in the trout’s brain. The results obtained have shown that the chronic effect of inorganic mercury causes dose-dependent oxidative stress in the fish brain. In addition, low concentrations of mercury (10 and 20 μg/L) caused a decrease in the content of ERCC1 in the brain of fish. On the contrary, the same doses have caused an increase in PARP1 expression. That is the chronic influence of low concentrations of inorganic mercury has a negative effect in the fish brain. Observed results showed that inorganic mercury has a potential for suppressing DNA repair and, therefore, increases the instability of genome. Thus, ERCC1 and PARP1 can be considered as the sensitive biomarkers of mercury cytotoxicity in the fish brain. A further study of mercury neurotoxicity is needed to find out the hazard of mercury environmental pollution as well as a validation of biomarkers of their impact.

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Geno- and cytotoxicity induced on Cyprinus carpio by aluminum, iron, mercury and mixture thereof

Cited by 20 publications

References 85 publications

Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio

Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

Indices of the DNA repair system in the brain of fish as a biomarker of inorganic mercury burden

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