Genome Analysis of the Marine Bacterium Labrenzia sp. Strain 011, a Potential Protective Agent of Mollusks

Abstract

The marine bacterium Labrenzia sp. strain 011 was isolated from the coastal sediment of Kronsgaard, Germany. The Labrenzia species are suggested to be protective agents of mollusks. Labrenzia sp. strain 011 produces specialized metabolites, which showed activity against a range of microorganisms, thereunder strong inhibitory effects against Pseudoroseovarius crassostreae DSM 16,950 (genus Roseovarius), the causative agent of oyster disease. The genome of Labrenzia sp. strain 011 was sequenced and assembled into 65 contigs, has a size of 5.1 Mbp, and a G+C content of 61.6%. A comparative genome analysis defined Labrenzia sp. strain 011 as a distinct new species within the genus Labrenzia, whereby 44% of the genome was contributed to the Labrenzia core genome. The genomic data provided here is expected to contribute to a deeper understanding of the mollusk-protective role of Labrenzia spp.

Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity

“…In order to elucidate the putative biosynthesis of compounds 1 and 2 , the genome of Labrenzia sp. 011 has recently been sequenced (accession number: QCYM00000000) [ 35 ]. The resulting genome was compared with further available genome sequences of the genus Labrenzia .…”

Recent highlights of biosynthetic studies on marine natural products

“…42,43 Bacteria of the genus Labrenzia are known as surface colonizers in marine environments and are suggested to act as protective symbionts of oysters. 44 In a recent study, Labrenzia sp. strain 011, isolated from Baltic Sea coastal sediment was found to produce two medium-chain fatty acids containing a cyclopropane moiety: cis-4-(2-hexylcyclopropyl)-butanoic acid (1) and cis-2-(2-hexylcyclopropyl)-acetic acid (2).…”

“…strain 011, isolated from Baltic Sea coastal sediment was found to produce two medium-chain fatty acids containing a cyclopropane moiety: cis-4-(2-hexylcyclopropyl)-butanoic acid (1) and cis-2-(2-hexylcyclopropyl)-acetic acid (2). 44,45 Both compounds were isolated using absorber resin Sepabeads from 20 L culture and the structures were established by NMR analyses. Activity studies revealed their inhibition activity against a range of bacteria and fungi, including a causative agent of Roseovarius oyster disease (ROD), Pseudoroseovarius crassostreae DSM 16950.…”