Genome architecture of Lactobacillus plantarum PS128, a probiotic strain with potential immunomodulatory activity

Liu, Wei Hsien; Yang, Chih Hsien; Lin, Ching Ting; Li, Shiao Wen; Cheng, Wei Shen; Jiang, Yi; Wu, Chien Chen; Chang, Chia Hui; Tsai, Yao‐Chou

doi:10.1186/s13099-015-0068-y

Cited by 31 publications

(23 citation statements)

References 23 publications

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“…DSM 28632. The genome architecture of PS128 was reported previously [61]. In the present study, the PS128 product was provided by Bened Biomedical Co., Ltd. in the final form of capsules containing creamy white powders.…”

Section: Methodsmentioning

confidence: 88%

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu¹,

et al. 2019

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This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7–15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.

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Section: Methodsmentioning

confidence: 88%

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu¹,

et al. 2019

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“…Beneficial effects of PS128 TM on children with autism spectrum disorder (26), triathletes (27), and patients with major depressive disorder (28) have also been reported. PS128 TM may exert its psychotropic effects by altering monoamine neurotransmitter levels (22)(23)(24)(25), and modulating glucocorticoid (22), antiinflammatory, and anti-oxidative responses (21,22,27); however, the underlying mechanisms warrant further investigation. Despite the increase in the number of IT employees, the importance of the IT industry to the economy, and the high stress due to uncertainty and workload under time pressure, no study to date has investigated whether probiotics could help alleviate stress, sleep, or mood symptoms in highly stressed IT specialists.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, Lactobacillus plantarum PS128 TM (PS128 TM ), isolated from spontaneously fermented mustard greens in Taiwan ( 21 ), has been demonstrated to reduce anxiety- and depression-like behaviors ( 22 , 23 ), ameliorate tic-like behaviors ( 24 ), and improve visceral hypersensitivity ( 25 ) in experimental animals. Beneficial effects of PS128 TM on children with autism spectrum disorder ( 26 ), triathletes ( 27 ), and patients with major depressive disorder ( 28 ) have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Wu²,

Tsai³

et al. 2021

Front. Nutr.

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Background: Information technology (IT) is an industry related to the production of computers, information processing, and telecommunications. Such industries heavily rely on the knowledge and solutions provided by IT specialists. Previous reports found that the subjective stress scores were higher in IT specialists who developed diabetes, hypertension, and depression. Specific probiotics, known as psychobiotics, may alleviate stress and mood symptoms. This study aimed to examine whether an 8-week intervention of a novel psychobiotic, Lactobacillus plantarum PS128TM (PS128TM), improved self-perceived stress and mood symptoms among high-stress IT specialists.Methods: This open-label, single-arm, baseline-controlled study included IT specialists from a large IT company in Northern Taiwan. Participants with a Perceived Stress Scale (PSS) 10-item version score of 27 or higher were included. Participants were asked to take two capsules containing PS128TM powder, equivalent to 20 billion colony-forming units, daily. Self-report measures, such as the Job Stress Scale, Visual Analog Scale of Stress, the Insomnia Severity Index, the State and Trait Anxiety Index, the Questionnaire for Emotional Trait and State, the Patient Health Questionnaire, the Quality of Life Enjoyment and Satisfaction Questionnaire, and Gastrointestinal Severity Index were compared at baseline and at the end of the trial period. The primary outcome was a 20% reduction in the PSS score at endpoint. Objective measures included salivary levels of stress biomarkers, including cortisol, α-amylase, immunoglobulin A, lactoferrin, and lysozymes, as well as results of the Test of Attentional Performance.Results: Of the 90 eligible IT specialists, 36 met the inclusion criteria. After the 8-week trial period, significant improvements in self-perceived stress, overall job stress, job burden, cortisol level, general or psychological health, anxiety, depression, sleep disturbances, quality of life, and both positive and negative emotions were found.Conclusion: Our results suggest that PS128TM has the distinct advantage of providing stress relief and can improve mental health for people with a high-stress job. Future placebo-controlled studies are warranted to explore the effect and underlying mechanisms of action of PS128TM.Clinical Trial Registration:https://clinicaltrials.gov/ (identifier: NCT04452253-sub-project 2).

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“…In addition, L. reuteri ameliorated the impaired social behavior observed in ASD animal models [ 46 , 47 ]. Anxiety- and depression-like behaviors observed in early life stressed (ELS) animals were recovered by the treatment of L. plantarum PS128, which reduced inflammation and corticosterone and increased dopamine and serotonin [ 113 , 114 ]. Another study reported that behavioral changes induced by chronic restraint stress were rescued by L. helveticus NS8, which increased serotonin and BDNF in the hippocampus [ 115 ].…”

Section: Probiotics For the Prevention Or The Treatment Of Mental Dismentioning

confidence: 99%

Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain

Choi

Koo

2020

Exp Neurobiol

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Often called the second brain, the gut communicates extensively with the brain and vice versa. The conversation between these two organs affects a variety of physiological mechanisms that are associated with our mental health. Over the past decade, a growing body of evidence has suggested that the gut microbiome builds a unique ecosystem inside the gastrointestinal tract to maintain the homeostasis and that compositional changes in the gut microbiome are highly correlated with several mental disorders. There are ongoing efforts to treat or prevent mental disorders by regulating the gut microbiome using probiotics. These attempts are based on the seminal findings that probiotics can control the gut microbiome and affect mental conditions. However, some issues have yet to be conclusively addressed, especially the causality between the gut microbiome and mental disorders. In this review, we focus on the mechanisms by which the gut microbiome affects mental health and diseases. Furthermore, we discuss the potential use of probiotics as therapeutic agents for psychiatric disorders.

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Genome architecture of Lactobacillus plantarum PS128, a probiotic strain with potential immunomodulatory activity

Cited by 31 publications

References 23 publications

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain

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