Genome-Based Vaccinology Applied to Bovine Babesiosis

Mosqueda, Juan; Hernández-Silva, Diego Josimar; MarioHidalgo-Ruiz,

doi:10.5772/intechopen.72636

Cited by 3 publications

(3 citation statements)

References 78 publications

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“…Studies of other apicomplexans of economic and clinical interest such as Babesia , the causative agent of babesiosis in many vertebrates including human and transmitted by ticks [261], have revealed important data about this protist. Babesia bovis has a genome with a size of 9.4 Mb that is organized in four chromosomes [262,263]. It is one of the smallest apicomplexan genomes found so far.…”

Section: Phosphoglycerate Kinase In Protistsmentioning

confidence: 99%

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

et al. 2020

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Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the conversion of 1,3-bisphosphoglycerate (1,3BPGA) to 3-phosphoglycerate (3PGA). It also participates in gluconeogenesis, catalysing the opposite reaction to produce 1,3BPGA and ADP. Like most other glycolytic enzymes, PGK has also been catalogued as a moonlighting protein, due to its involvement in different functions not associated with energy metabolism, which include pathogenesis, interaction with nucleic acids, tumorigenesis progression, cell death and viral replication. In this review, we have highlighted the overall aspects of this enzyme, such as its structure, reaction kinetics, activity regulation and possible moonlighting functions in different protistan organisms, especially both free-living and parasitic Kinetoplastea. Our analysis of the genomes of different kinetoplastids revealed the presence of open-reading frames (ORFs) for multiple PGK isoforms in several species. Some of these ORFs code for unusually large PGKs. The products appear to contain additional structural domains fused to the PGK domain. A striking aspect is that some of these PGK isoforms are predicted to be catalytically inactive enzymes or ‘dead’ enzymes. The roles of PGKs in kinetoplastid parasites are analysed, and the apparent significance of the PGK gene duplication that gave rise to the different isoforms and their expression in Trypanosoma cruzi is discussed.

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Section: Phosphoglycerate Kinase In Protistsmentioning

confidence: 99%

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

et al. 2020

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“…microplus and R . annulatus have not been eradicated [ 10 , 11 ]. This poses the risk of re-emergence for CFT and bovine babesiosis in the U.S. [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Another binational agricultural activity involving tight international biosecurity is cattle trade between the U.S. and Mexico. Bovine babesiosis and CFT are endemic in Mexico and affect the health and productivity of cattle in areas where R. microplus and R. annulatus have not been eradicated [10,11]. This poses the risk of re-emergence for CFT and bovine babesiosis in the U.S. [12].…”

Section: Introductionmentioning

confidence: 99%

Research on Integrated Management for Cattle Fever Ticks and Bovine Babesiosis in the United States and Mexico: Current Status and Opportunities for Binational Coordination

et al. 2020

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Bovine babesiosis is a reportable transboundary animal disease caused by Babesia bovis and Babesiabigemina in the Americas where these apicomplexan protozoa are transmitted by the invasive cattle fever ticks Rhipicephalus (Boophilus) microplus and Rhipicephalus(Boophilus) annulatus. In countries like Mexico where cattle fever ticks remain endemic, bovine babesiosis is detrimental to cattle health and results in a significant economic cost to the livestock industry. These cattle disease vectors continue to threaten the U.S. cattle industry despite their elimination through efforts of the Cattle Fever Tick Eradication Program. Mexico and the U.S. share a common interest in managing cattle fever ticks through their economically important binational cattle trade. Here, we report the outcomes of a meeting where stakeholders from Mexico and the U.S. representing the livestock and pharmaceutical industry, regulatory agencies, and research institutions gathered to discuss research and knowledge gaps requiring attention to advance progressive management strategies for bovine babesiosis and cattle fever ticks. Research recommendations and other actionable activities reflect commitment among meeting participants to seize opportunities for collaborative efforts. Addressing these research gaps is expected to yield scientific knowledge benefitting the interdependent livestock industries of Mexico and the U.S. through its translation into enhanced biosecurity against the economic and animal health impacts of bovine babesiosis and cattle fever ticks.

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Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle

Hidalgo-Ruiz

Mejia-López

Pérez-Serrano

et al. 2022

Vaccine

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Genome-Based Vaccinology Applied to Bovine Babesiosis

Cited by 3 publications

References 78 publications

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

Research on Integrated Management for Cattle Fever Ticks and Bovine Babesiosis in the United States and Mexico: Current Status and Opportunities for Binational Coordination

Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle

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