2022
DOI: 10.1101/2022.03.11.22272206
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Genome-by-Trauma Exposure Interaction Effects in Depression

Abstract: Background Self-reported trauma exposure has consistently been found to be a risk factor for Major Depressive Disorder (MDD) and several studies have reported interactions with genetic liability. To date, most studies have examined interaction effects with trauma exposure using genome-wide variants (single nucleotide polymorphisms SNPs) or polygenic scores, both typically capturing less than 3% of phenotypic risk variance. We sought to re-examine genome-by-trauma interaction effects using genetic measures uti… Show more

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