Genome distribution, chromosomal allocation, and organization of the major and minor satellite DNAs in 11 species and subspecies of the genus Mus

Garagna, Silvia; Redi, Carlo Alberto; Capanna, Ernesto; Andayani, Noviar; Alfano, Rosa Maria; Doi, Patrizia; Viale, Giulia

doi:10.1159/000133587

Cited by 44 publications

(43 citation statements)

References 7 publications

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“…Data we have recently obtained in Mus domesticus by banding after restriction enzyme digestion (Garagna et al, 1992), Southern blot analysis and the energy transfer test (Garagna et al, 1993) demonstrate a very peculiar location and structure of the satellite DNA sequence in long tandem repeat sequences that fit our proposed model very well, because homologous sequences appear to be sequentially reiterated so as to increase the probability of DNA-DNA hybridization between centromeres of different chromosomes.…”

Section: An Alloperipatric Model Of Chromosome Speciationsupporting

confidence: 59%

Chromosomes and microevolutionary processes

Capanna

Redi

1994

Bollettino di zoologia

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The role of chromosomal rearrangement in microevolutionary processes is discussed, considering numerous aspects of the complex mechanisms of chromosomal speciation. The different degrees of chromosome-derived subfertility, a consequence of the different kinds of structural heterozygosities in the inter-racial hybrids, are discussed with reference to the effectiveness of the postmating reproductive barrier. A «non meiotic» view of the reproductive fitness of the Robertsonian heterozygotes and homozygotes is proposed. It is based on the possibility that Robertsonian fusion, and chromosomal structural rearrangement in general, may alter the internal topography of interphasic nucleus. Consequent upon any such change would be an alteration in the collocation of the gene clusters in the nuclear domains programmed for their regular function. It is claimed that these considerations explain the selective advantage that the new homokaryotype must have over the nonrearranged type for the new chromosomal variant to be fixed and maintained within a panmyctic population. Also discussed are the role of the demographic factors involved in chromosomal speciation and the molecular mechanisms responsible for the chromosomal rearrangement. An alloperipatric model of chromosomal speciation seems not to conflict with the «geographical» speciation principle of Mayr, and to be fully justified in terms of biological theory.

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Section: An Alloperipatric Model Of Chromosome Speciationsupporting

confidence: 59%

Chromosomes and microevolutionary processes

Capanna

Redi

1994

Bollettino di zoologia

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“…Previous studies have shown that minor satellite is present in varying amounts on Rob chromosomes. This suggests that different exchange sites within the minor satellite array and͞or the subsequent loss of minor satellite sequences are possible through processes such as unequal crossing over or looping out unstable inverted minor satellite sequences generated from the translocation events (25,(28)(29)(30). Rob translocations constitute the most common chromosomal rearrangement observed in humans.…”

Section: Discussionmentioning

confidence: 99%

Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation

Kalitsis

Griffiths

Choo

2006

Proc. Natl. Acad. Sci. U.S.A.

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The telomere and centromere are two specialized structures of eukaryotic chromosomes that are essential for chromosome stability and segregation. These structures are usually characterized by large tracts of tandemly repeated DNA. In mouse, the two structures are often located in close proximity to form telocentric chromosomes. To date, no detailed sequence information is available across the mouse telocentric regions. The antagonistic mechanisms for the stable maintenance of the mouse telocentric karyotype and the occurrence of whole-arm Robertsonian translocations remain enigmatic. We have identified large-insert fosmid clones that span the telomere and centromere of several mouse chromosome ends. Sequence analysis shows that the distance between the telomeric T 2AG3 and centromeric minor satellite repeats range from 1.8 to 11 kb. The telocentric regions of different mouse chromosomes comprise a contiguous linear order of T2AG3 repeats, a highly conserved truncated long interspersed nucleotide element 1 repeat, and varying amounts of a recently discovered telocentric tandem repeat that shares considerable identity with, and is inverted relative to, the centromeric minor satellite DNA. The telocentric domain as a whole exhibits the same polarity and a high sequence identity of >99% between nonhomologous chromosomes. This organization reflects a mechanism of frequent recombinational exchange between nonhomologous chromosomes that should promote the stable evolutionary maintenance of a telocentric karyotype. It also provides a possible mechanism for occasional inverted mispairing and recombination between the oppositely oriented TLC and minor satellite repeats to result in Robertsonian translocations.centromere ͉ chromosome ͉ evolution ͉ telomere

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“…In fact, several patterns of rep DNA-karyotype changes have been described, and practically all the possible combination of changes, and non-changes, of the two parame ters have been found, totally confusing our view of the phenom enon, one finding the example that better fits his own view of genome restructuring during evolution (Hatch et al, 1976, in the kangaroo rats of the genus Dipodomys; Patton and Sher wood, 1983, in the pocket gophers of the talpoides and hottae species group of the genus Thomomys; Garagna et al [1993Garagna et al [ , 1995, in 2n differently set up house mouse Mus domestieus wild populations). Thus, apparently it is not possible to formu late a unifying theory accounting for the role played by rep DNA in karyotype restructuring.…”

Section: Discussionmentioning

confidence: 99%

Genome composition in Venezuelan spiny-rats of the genus <i>Proechimy</i><i>s</i> (Rodentia, Echimyidae). I. Genome size, C-heterochromatin and repetitive DNAs in situ hybridization patterns

Garagna

Pérez-Zapata²,

Zuccotti

et al. 1997

Cytogenet Genome Res

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The genome sizes of the Venezuelan spiny-rats Proechimys guairae guairae (2n = 48) and P. trinitatis (2n = 62) were evaluated and proved to be 12.5 ± 0.5pg and 12.6 ± 0.3pg respectively, the highest so far recorded among mammals; also the C-heterochromatin (32.7 %, Coefficient of Variation [CV] 3.8 and 35.8%, CV4.4) and GC (44.2%, CV2.7 and 43.6%, CV 2.9) contents are very high. Highly repetitive (rep) DNAs were isolated from restriction enzyme digested genomic DNAs of both species. The intra- and inter-specific chromosomal allocations of these rep DNAs were analyzed by direct and cross-hybridizations. Results show that the two genomes harbour several rep DNA families which show both species-specificity and interspecific relatedness in their in situ hybridization patterns. The rep DNA families show an equilocal distribution at both the pericentromeric areas of all chromosomes and in the whole arms of two pairs of the uniarmed group, suggesting co-evolution of the rep DNAs. P. g. guairae BamHI digested DNA, when cloned and sequenced, proved to consist of a long “composite” unit (1,239 bp) containing two copies of each of 75-bp and 110-bp internal subrepeats. Karyotype restructuring between P. g. guairae and P. trinitatis, mainly due to Robertsonian changes, was accompanied by slight intra- and intergenomic movements of the putative satellite DNA families within stable genome sizes and C-heterochromatin contents. We discuss the findings obtained in Proechimys in the light of those regarding the kangaroo rat, the pocket gopher and the house mouse; they support the idea that karyotype restructuring could be the expression of molecular driven events of rep DNA amplification and homogenisation through non-homologous chromosomes.

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Genome distribution, chromosomal allocation, and organization of the major and minor satellite DNAs in 11 species and subspecies of the genus Mus

Cited by 44 publications

References 7 publications

Chromosomes and microevolutionary processes

Chromosomes and microevolutionary processes

Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation

Genome composition in Venezuelan spiny-rats of the genus <i>Proechimy</i><i>s</i> (Rodentia, Echimyidae). I. Genome size, C-heterochromatin and repetitive DNAs in situ hybridization patterns

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