2021
DOI: 10.1155/2021/6662027
|View full text |Cite
|
Sign up to set email alerts
|

Genome Features and In Vitro Activity against Influenza A and SARS‐CoV‐2 Viruses of Six Probiotic Strains

Abstract: Purpose. The aim of this work was to analyze the complete genome of probiotic bacteria Lactobacillus plantarum 8 RA 3, Lactobacillus fermentum 90 TC-4, Lactobacillus fermentum 39, Bifidobacterium bifidum 791, Bifidobacterium bifidum 1, and Bifidobacterium longum 379 and to test their activity against influenza A and SARS-CoV-2 viruses. Methods. To confirm the taxonomic affiliation of the bacterial strains, MALDI TOF mass spectrometry and biochemical test systems were used. Whole genome sequencing was performed… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
20
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 13 publications
(20 citation statements)
references
References 31 publications
0
20
0
Order By: Relevance
“…To the best of our knowledge, no study has reported the effect of immunomodulatory probiotic lactobacilli against SARS-CoV-2 infection. One report used Vero E6 cells stimulated with lactobacilli for 2 h before the challenge with SARS-CoV-2 and evaluated the viability of infected cells by using the MTT test after 3 days post-infection [ 39 ]. The work described that the treatment of Vero E6 cells with Limosilactobacillus fermentum 90TC4 significantly increased the viability of cells challenged with SARS-CoV-2 when compared to infected controls.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge, no study has reported the effect of immunomodulatory probiotic lactobacilli against SARS-CoV-2 infection. One report used Vero E6 cells stimulated with lactobacilli for 2 h before the challenge with SARS-CoV-2 and evaluated the viability of infected cells by using the MTT test after 3 days post-infection [ 39 ]. The work described that the treatment of Vero E6 cells with Limosilactobacillus fermentum 90TC4 significantly increased the viability of cells challenged with SARS-CoV-2 when compared to infected controls.…”
Section: Discussionmentioning
confidence: 99%
“…cell-free supernatant, heat-killed supernatant, and cell-mass), the cell-free supernatant showed the most efficient anti-influenza A activity against host cells (Rather et al, 2015 ). In other studies, the supernatant obtained from L. plantarum 8 RA 3 suspension displayed a significant inhibitory effect on viral reproduction in vitro (Soloveva et al, 2021 ), and the supernatant of L. plantarum CQ2017RC suspension repressed the replication of porcine epidemic diarrhea virus (Huang et al, 2021 ). Furthermore, the exopolysaccharides (EPS), one of the major components in the supernatant, was revealed to be the key active component, affecting the viral infectivity and host immune response (Huang et al, 2021 ).…”
Section: Curcuminmentioning
confidence: 91%
“…L. plantarum is a lactic acid bacteria which exists in various types of food (Arasu et al, 2016 ). Certain strains from this species appear to exert antiviral effects against several types of viruses (Arena et al, 2018 ; Huang et al, 2021 ; Kim et al, 2018 ; Liu et al, 2020 ; Park et al, 2013 ; Rather et al, 2015 ; Soloveva et al, 2021 ; Sunmola et al, 2019 ). According to a report, intranasal or oral treatment of L. plantarum strain DK119 (10 9 CFU per mouse), protected the mice from influenza A virus infection, reducing lethality, weight loss, and virion loads in the lungs (Park et al, 2013 ).…”
Section: Curcuminmentioning
confidence: 99%
See 1 more Smart Citation
“…Although vaccines for SARS-CoV-2 are available, the rapidly SARS-CoV-2 mutating makes the effectiveness of these vaccines challenging ( 60 ). Notably, in vitro experiment has demonstrated that L. fermentum 90 TC-4 pretreatment increases the activity of SARS-CoV-2-infected Vero E6 cells (grass monkey kidney cells) ( 61 ). Pretreatment of L. plantarum MPL16 and CRL1506 can also inhibit the proliferation of SARS-CoV-2 in human lung epithelial cell line Calu-3 ( 62 ).…”
Section: Beneficial Role Of Lactobacillus In Respi...mentioning
confidence: 99%