Genome Mining and Analysis of PKS Genes in Eurotium cristatum E1 Isolated from Fuzhuan Brick Tea

Guo, Xiaoxiao; Chen, Fusheng; Liu, Jiao; Shao, Yanchun; Wang, Xiaohong; Zhou, Youxiang

doi:10.3390/jof8020193

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Chemical investigation of these lipophilic FBT components led to the characterization of four phenol analogs, namely, isodihydroauroglaucin (1), dihydroauroglaucin (2), tetrahydroauroglaucin (3), and flavoglaucin (4). All of these compounds belong to benzaldehyde-derived phenols, which are biosynthesized through the polyketide pathway [21,52]. Isodihydroauroglaucin (1) was first identified from the fungus of A. ruber [36].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by Eurotium cristatum

Song

Dai

et al. 2022

Foods

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Fuzhuan brick tea (FBT), a type of black tea, is a traditional beverage in China, especially popular among frontier ethnic groups. FBT is well-known for its health benefits, such as hypoglycemic, anti-hypertensive, anti-inflammatory, diuretic, and detoxification effects. Nevertheless, the underlying mechanisms on the molecular level are still elusive and the key compounds responsible for the health benefits are unidentified. Previous studies have mainly focused on functional studies of the water extract. However, FBT is typically cooked with butter or milk. Therefore, we hypothesized that some lipophilic components in FBT, which can be absorbed through the co-consumption of butter or milk, may play an important role in the health benefits. The present study aimed to investigate whether the liposoluble extract of FBT alleviates symptoms related to metabolic diseases and to identify the active compounds involved. By comparing the high-performance liquid chromatography (HPLC) profiles of water, milk and hexane extract, some low polarity peaks were observed in the milk and hexane extracts. Furthermore, the hexane extract treatment alleviated body weight gain, serum total cholesterol and triglyceride levels, and inhibited the accumulation of hepatic fat granules in a high-fat diet (HFD)-induced C57BL/6N mouse model. In order to identify the key functional lipophilic compounds in FBT, the hexane extract of FBT was subjected to chemical characterization. Four phenol analogs were characterized, namely, isodihydroauroglaucin (1), dihydroauroglaucin (2), tetrahydroauroglaucin (3), and flavoglaucin (4). Compounds 1 and 4 reduced the levels of total cholesterol and triglyceride in vivo. Both compounds also inhibited the high-fat diet-induced body weight gain and accumulation of fat granules in the liver of C57BL/6N mice. Isodihydroauroglaucin and flavoglaucin have therefore been identified as bioactive ingredients that contribute to the health benefits of FBT.

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Section: Discussionmentioning

confidence: 99%

Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by Eurotium cristatum

Song

Dai

et al. 2022

Foods

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“…The antioxidative and synergistic effects of flavoglaucin and its derivatives largely depend on their hydroxy group, which does not form hydrogen bonds with the formyl group in the molecule. These compounds are found in a variety of foods fermented by Eurotium and contribute to their functional activity [78]. Li et al [51] assessed the antioxidative activity of metabolites isolated from a marine mangrove plant-derived endophytic fungus E. rubrum using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay.…”

Section: Antioxidative Activitymentioning

confidence: 99%

Secondary Metabolites from the Genus Eurotium and Their Biological Activities

Deng,

Li,

Yuan

et al. 2023

Foods

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Eurotium is the teleomorph genus associated with the section Aspergillus. Eurotium comprises approximately 20 species, which are widely distributed in nature and human environments. Eurotium is usually the key microorganism for the fermentation of traditional food, such as Fuzhuan brick tea, Liupao tea, Meju, and Karebushi; thus, Eurotium is an important fungus in the food industry. Eurotium has been extensively studied because it contains a series of interesting, structurally diverse, and biologically important secondary metabolites, including anthraquinones, benzaldehyde derivatives, and indol diketopiperazine alkaloids. These secondary metabolites have shown multiple biological activities, including antioxidative, antimicrobial, cytotoxic, antitumor, insecticidal, antimalarial, and anti-inflammatory activities. This study presents an up-to-date review of the phytochemistry and biological activities of all Eurotium species. This review will provide recent advances on the secondary metabolites and their bioactivities in the genus Eurotium for the first time and serve as a database for future research and drug development from the genus Eurotium.

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Role of Pmk1, Mpk1, or Hog1 in the mitogen-activated protein kinase pathway of Aspergillus cristatus

Liu,

Li,

et al. 2024

Fungal Genetics and Biology

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Genome Mining and Analysis of PKS Genes in Eurotium cristatum E1 Isolated from Fuzhuan Brick Tea

Cited by 5 publications

References 52 publications

Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by Eurotium cristatum

Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by Eurotium cristatum

Secondary Metabolites from the Genus Eurotium and Their Biological Activities

Role of Pmk1, Mpk1, or Hog1 in the mitogen-activated protein kinase pathway of Aspergillus cristatus

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