Genome‐Scale Models

Palsson, Bernhard Ø.

doi:10.1002/9783527823468.ch2

Cited by 2 publications

(2 citation statements)

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“…[65] From Greenland, Auun headed back to Norway, possibly initially via More again, with an intention of sailing to gift the bear to the King of Denmark. [66] However, he was detained, shortly, by the King of Norway, [67] possibly near Bergen (Figure 18). Auun travelled onto Denmark via 'Oslofjord' to give Denmark's King the bear, [68] possibly at the then Danish capital of Roskilde (Figure 19).…”

Section: Auun and A Bearmentioning

confidence: 99%

Beyond Raiding: Unveiling the Epic Voyages of the Vikings (793-1066 AD)

Conroy

2024

Preprint

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This essay charts a course beyond the stereotypical image of Vikings as mere raiders. It navigates the vast distances traversed by the Northmen -a broader term encompassing Scandinavians and their neighboursduring the 9th-11th centuries. While acknowledging the scholarly debate surrounding the term "Viking," the focus here is on their remarkable journeys as explorers and settlers.Despite limitations in source reliability, the essay employs a modern navigational tool to estimate the staggering distances covered by these intrepid seafarers. We encounter the pioneering Irish monks (Papar) who likely reached Iceland first, followed by Northmen settlers like Ingolfr, whose saga unfolds across hundreds of nautical miles. Eirík the Red emerges as a bold adventurer, leading the first Norse settlement in the icy embrace of Greenland.The essay then delves into the exploration of North America (Vínland), crediting Leif Eiríksson with its discovery and detailing subsequent expeditions undertaken by Thorvald and Thorfinn Karlsefni. Compelling figures like Gudrid, who traversed a distance exceeding the breadth of the entire North American continent in her lifetime, showcase the immense scale of these voyages.The essay culminates by highlighting Auun's remarkable odyssey, exceeding a staggering 9,413 miles, which even included a polar bear as a royal gift! By unveiling the Northmen's incredible feats of navigation and exploration, this essay offers a more nuanced perspective on these historical adventurers. It concludes by calling for further investigation into the specific locations mentioned in sagas to gain a richer understanding of their journeys and daily lives, forever etching their stories onto the map of human exploration.

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Section: Auun and A Bearmentioning

confidence: 99%

Beyond Raiding: Unveiling the Epic Voyages of the Vikings (793-1066 AD)

Conroy

2024

Preprint

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“…Most of the past and current efforts of synthetic biology have been focusing on microbial models, due to their relative simplicity, and this preference will most likely dominate the future, although mammalian stem cells have gained much interest in recent times. Similarly, computational models addressing microbial pathway systems will eventually become the standard for rational metabolic engineering (Alvarez-Vasquez et al, 2000;Harder et al, 2016;Gudmundsson and Nogales, 2021;Palsson et al, 2021). Applications in this field are manifold.…”

Section: Other Microbial Applicationsmentioning

confidence: 99%

What’s next for computational systems biology?

Voit,

Shah,

Olivença

et al. 2023

Front. Syst. Biol.

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Largely unknown just a few decades ago, computational systems biology is now a central methodology for biological and medical research. This amazing ascent raises the question of what the community should do next. The article outlines our personal vision for the future of computational systems biology, suggesting the need to address both mindsets and methodologies. We present this vision by focusing on current and anticipated research goals, the development of strong computational tools, likely prominent applications, education of the next-generation of scientists, and outreach to the public. In our opinion, two classes of broad research goals have emerged in recent years and will guide future efforts. The first goal targets computational models of increasing size and complexity, aimed at solving emerging health-related challenges, such as realistic whole-cell and organ models, disease simulators and digital twins, in silico clinical trials, and clinically translational applications in the context of therapeutic drug development. Such large models will also lead us toward solutions to pressing issues in agriculture and environmental sustainability, including sufficient food availability and life in changing habitats. The second goal is a deep understanding of the essence of system designs and strategies with which nature solves problems. This understanding will help us explain observed biological structures and guide forays into synthetic biological systems. Regarding effective methodologies, we suggest efforts toward automated data pipelines from raw biomedical data all the way to spatiotemporal mechanistic model. These will be supported by dynamic methods of statistics, machine learning, artificial intelligence and streamlined strategies of dynamic model design, striking a fine balance between modeling realistic complexity and abstracted simplicity. Finally, we suggest the need for a concerted, community-wide emphasis on effective education in systems biology, implemented as a combination of formal instruction and hands-on mentoring. The educational efforts should furthermore be extended toward the public through books, blogs, social media, and interactive networking opportunities, with the ultimate goal of training in state-of-the-art technology while recapturing the lost art of synthesis.

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Genome‐Scale Models

Cited by 2 publications

References 116 publications

Beyond Raiding: Unveiling the Epic Voyages of the Vikings (793-1066 AD)

Beyond Raiding: Unveiling the Epic Voyages of the Vikings (793-1066 AD)

What’s next for computational systems biology?

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