Genome Sequence of a Gyrovirus Associated with Ashy Storm-Petrel

Waits, Kara; Bradley, Russell W.; Warzybok, Pete; Kraberger, Simona; Fontenele, Rafaela S.; Varsani, Arvind

doi:10.1128/mra.00958-18

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…GyV8 was found in one northern fulmar showing ataxia and head tilt, but no other fulmar with similar clinical signs analyzed resulted positive for GyV8 [17]. ASPaGyV was discovered in cloacal samples from ashy storm petrels [19]. The presence of GyV11 was detected in three different birds from the Nouragues Natural Reserve, but only one of them was found to be positive in both cloacal and blood samples, thus supporting the idea of a possible systemic infection.…”

Section: Discussionmentioning

confidence: 70%

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

Truchado

Diaz-Piqueras

Gómez-Lucı́a

et al. 2019

Viruses

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Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and blood samples from neotropical wild birds in French Guiana. The molecular epidemiology revealed the presence of GyV11 only in passerine birds from three different species at a low prevalence (0.73%). This is the first characterization and prevalence study of a gyrovirus carried out in resident wild bird populations in a remote region, and provides evidence of the fecal-oral route transmission and local circulation of the virus. The molecular phylogeny of gyroviruses reveals the existence of two distinct gyrovirus lineages in which GyV11 is phylogenetically distinct from previously reported gyroviruses. Furthermore, GyV11 is placed basal in the gyrovirus phylogeny, likely owing to its ancestral origin and marked divergence. This study also provides important insights into the ecology, epidemiology, and genomic features of gyroviruses in a remote neotropical rainforest. The pathogenesis of this virus in avian species or whether GyV11 can infect humans and/or chickens needs to be further investigated.

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Section: Discussionmentioning

confidence: 70%

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

Truchado

Diaz-Piqueras

Gómez-Lucı́a

et al. 2019

Viruses

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“…Gyroviruses occur in mammals and birds; in mammals, the source of detection is typically the feces, while in birds, gyroviruses can also be detected in tissue samples [35]. With the exception of chicken anemia virus (Gyrovirus chickenanemia), which is an immunosuppressive agent in chicken, other gyrovirus species are not known to cause diseases in the avian host species in which they have been identified, or the putative pathologic findings have yet to be confirmed [36][37][38][39][40][41][42][43]. In this study, we identified gyrovirus genomic traits in 12 sample pools originating from 5 counties between 2008 and 2011.…”

Section: Discussionmentioning

confidence: 99%

Metagenomic Identification of Novel Eukaryotic Viruses with Small DNA Genomes in Pheasants

Kaszab,

Bali,

Marton

et al. 2024

Animals

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A panel of intestinal samples collected from common pheasants (Phasianus colchicus) between 2008 and 2017 was used for metagenomic investigation using an unbiased enrichment protocol and different bioinformatic pipelines. The number of sequence reads in the metagenomic analysis ranged from 1,419,265 to 17,507,704 with a viral sequence read rate ranging from 0.01% to 59%. When considering the sequence reads of eukaryotic viruses, RNA and DNA viruses were identified in the samples, including but not limited to coronaviruses, reoviruses, parvoviruses, and CRESS DNA viruses (i.e., circular Rep-encoding single-stranded DNA viruses). Partial or nearly complete genome sequences were reconstructed of at least three different parvoviruses (dependoparvovirus, aveparvovirus and chaphamaparvovirus), as well as gyroviruses and diverse CRESS DNA viruses. Generating information of virus diversity will serve as a basis for developing specific diagnostic tools and for structured epidemiological investigations, useful to assess the impact of these novel viruses on animal health.

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“…CAV is found worldwide and causes significant mortality among chicks not protected by maternal antibodies. Other gyroviruses have been identified in diseased avian hosts, including in seabirds (15)(16)(17)(18)(19). Herein, we describe a new gyrovirus associated with RDS in yellow-eyed penguins.…”

Section: Introductionmentioning

confidence: 95%

“…To infer the evolutionary history of yellow-eyed penguin gyrovirus, we estimated phylogenetic trees for both VP1 and VP2 among other known gyroviruses using Torque teno virus 1, a nongyrovirus member of the Anelloviridae, as an outgroup (Figure 3). Within VP1, yellow-eyed gyrovirus clustered with Gyrovirus 8, which caused disease in the northern fulmar, while VP2 fell within a clade of gyroviruses infecting seabirds, including Ashy storm-petrel gyrovirus (16). We next inferred the phylogeography of all full and partial yellow-eyed gyrovirus genomes obtained (34 of 43 samples) across the three sampling sites (Figure 4).…”

Section: Genome Organisation and Phylogenetic Characterisation Of A N...mentioning

confidence: 99%

A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks

Wierenga

Morgan

Hunter

et al. 2022

Preprint

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Yellow-eyed penguins (Megadyptes antipodes), or hoiho in te reo Māori, are predicted to become extinct on mainland Aotearoa New Zealand in the next few decades, with infectious disease a significant contributor to their decline. A recent disease phenomenon termed respiratory distress syndrome (RDS) causing lung pathology has been identified in very young chicks. To date, no causative pathogens for RDS have been identified. In 2020 and 2021, the number of chick deaths from suspected RDS increased four- and five-fold, respectively, with a mortality rate of >90%. Here, we aimed to identify possible pathogens responsible for RDS disease impacting yelloweyed penguins. Total RNA was extracted from tissue samples collected during post-mortem of 43 chicks and subject to metatranscriptomic sequencing. From these data we identified a novel and highly abundant gyrovirus in 80% of tissue samples. This virus exhibited only 41% amino acid identity within VP1 to its closest relative, Gyrovirus 8, discovered in a diseased seabird. No other exogenous viral transcripts, nor pathogenic bacterial, protozoal and fungal organisms, were identified in these tissues. Due to the high relative abundance of viral reads, it is likely that this novel gyrovirus is associated with RDS in yellow-eyed penguin chicks.Author SummaryNew Zealand’s population of yellow-eyed penguins, also called hoiho, are predicted to become extinct in the next 20-30 years, with disease a major factor contributing to their decline. A new disease, causing fluid and bleeding into the lungs, was initially identified in 2019 in very young chicks. It was characterised as causing respiratory distress with a mortality of >90% usually within the first week of life. To date, no causative pathogens of the disease have been identified. We aimed to identify possible pathogens responsible for respiratory disease in these penguin chicks. A metatranscriptomic survey of dead chicks identified a novel and highly abundant gyrovirus present in diseased tissue, with closely related viruses causing disease in other avian hosts. It is, therefore, highly likely that this novel gyrovirus is associated with respiratory disease in these chicks. This finding offers the potential to increase the success of disease management in the critically endangered yellow-eyed penguin and possibly other at-risk penguin species. The potential to lessen mortality and slow the decline of the species is essential in protecting the biodiversity of New Zealand’s fauna and flora.

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Genome Sequence of a Gyrovirus Associated with Ashy Storm-Petrel

Cited by 10 publications

References 17 publications

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

Metagenomic Identification of Novel Eukaryotic Viruses with Small DNA Genomes in Pheasants

A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks

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