Genome Sequence of an Australian Kangaroo,Macropus eugenii

Abstract

The tammar wallaby ( Macropus eugenii ) is a model marsupial species that has been intensively used for research into various aspects of marsupial biology. Recently, it became one of only three marsupial species to have its genome sequenced. Comparisons of genome sequence from all three marsupials with those of other vertebrates have made it possible to begin identifying marsupial‐specific genome features. Our knowledge of the biology of the tammar wallaby has informed the interpretation of these unique features and provided insight into their evolution. Among these unique features are genes involved in the sophisticated marsupial lactation system and genes encoding for potent antimicrobial peptides. Comparisons of genome organisation have also provided insight into marsupial genome evolution. Key Concepts: Uncovering the genetic basis of unique marsupial features is now possible due to the availability of genome sequences for three marsupial species. The tammar wallaby is a model species used for studies into marsupial biology, making it possible to link genomic features with the biological characteristics. As the tammar wallaby genome was only lightly sequenced, other genomic resources such as transcriptome sequences and genome maps have enhanced the genome assembly. A number of novel genes are associated with the complex marsupial lactation system and immunity. Five novel genes have been identified on the marsupial Y chromosome. The organisation of the tammar wallaby major histocompatibility complex is vastly different to that of any other species studied to date. A decades old debate over chromosome number in the ancestral marsupial has been resolved by comparing genome organisation among the sequenced marsupials species and the outgroup species human and chicken. The wallaby genome assembly in combination with other genomic resources are proving valuable for the discovery of marsupial‐specific features.

A 16S Next Generation Sequencing Based Molecular and Bioinformatics Pipeline to Identify Processed Meat Products Contamination and Mislabelling

“…The kangaroo genome, on the other hand, was only first sequenced in 2011 [ 42 , 43 ], even though the benefits of sequencing the kangaroo genome where initially discussed and published in 2003 [ 44 ]. Further research on sequencing the kangaroo genome has been published [ 45 , 46 ], but there is a clear indication from the number of published articles that the kangaroo genome has been sequenced less than the cattle genome. Therefore, this may have resulted in an overestimation of cattle reads in the beef: kangaroo ratio mixture.…”