2014
DOI: 10.1186/1471-2164-15-42
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Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites

Abstract: BackgroundAnopheles sinensis is an important mosquito vector of Plasmodium vivax, which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan.ResultsWe performed 454 next-generation sequencing and obtained a draft sequence of A. sinensis assembled into scaffolds spanning 220.8 million base pairs. Analysis of this genome sequence, we observed expansion and contraction of several immune-related gene families in anopheline relative to c… Show more

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Cited by 60 publications
(47 citation statements)
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“…2C). Analysis by mass spectrometry (MS) identified the smaller polypeptide as a form of gSG7 (VectorBase, AALB001854-PA), a 13 kDa protein previously described from other anopheline species (1822). In the genomic sequence of An.…”
Section: Resultsmentioning
confidence: 99%
“…2C). Analysis by mass spectrometry (MS) identified the smaller polypeptide as a form of gSG7 (VectorBase, AALB001854-PA), a 13 kDa protein previously described from other anopheline species (1822). In the genomic sequence of An.…”
Section: Resultsmentioning
confidence: 99%
“…). Using BLASTn with AaegR4_1.1 and AgamR4_1.1 as queries to search 25 genomes for 22 species (Marinotti et al ., ; Zhou et al ., ; see http://onlinelibrary.wiley.com/doi/10.1111/imb.12160/suppinfo), R4 clade representatives were found only in species from two of the three genera, Aedes and Anopheles . More interesting is that AgamR4_1 ‐like representatives were only found in the An.…”
Section: Resultsmentioning
confidence: 99%
“…sinensis mosquitoes. We screened 24 publicly available Anopheles genomes (Holt et al 2002; Zhou et al 2014; Logue et al 2015; Neafsey et al 2015) for flaviviral sequences, and validated in silico hits both at the DNA and RNA levels in vivo . The two newly described flavivirus-derived EVEs are phylogenetically related to ISFs, and support the existence of a previously unsuspected Anopheles -associated clade of ISFs.…”
Section: Introductionmentioning
confidence: 99%