Genome Sequence of Elizabethkingia meningoseptica EM1, Isolated from a Patient with a Bloodstream Infection

Chen, Shicheng; Soehnlen, Marty; Walker, Edward D.

doi:10.1128/genomea.01137-16

Cited by 2 publications

(1 citation statement)

References 10 publications

(12 reference statements)

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“…Whole-genome research conducted on E. meningoseptica has identified numerous putative genes conferring antibiotic resistance [19,69]. However, only a few homologs have been further investigated.…”

Section: Antimicrobial Susceptibility Testing and Antibiotic Resismentioning

confidence: 99%

Elizabethkingia Infections in Humans: From Genomics to Clinics

et al. 2019

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The genus Elizabethkingia has recently emerged as a cause of life-threatening infections in humans, particularly in immunocompromised patients. Several new species in the genus Elizabethkingia have been proposed in the last decade. Numerous studies have indicated that Elizabethkingia anophelis, rather than Elizabethkingia meningoseptica, is the most prevalent pathogen in this genus. Matrix-assisted laser desorption/ionization–time of flight mass spectrometry systems with an extended spectrum database could reliably identify E. anophelis and E. meningoseptica, but they are unable to distinguish the remaining species. Precise species identification relies on molecular techniques, such as housekeeping gene sequencing and whole-genome sequencing. These microorganisms are usually susceptible to minocycline but resistant to most β-lactams, β-lactam/β-lactam inhibitors, carbapenems, and aminoglycosides. They often exhibit variable susceptibility to piperacillin, piperacillin-tazobactam, fluoroquinolones, and trimethoprim-sulfamethoxazole. Accordingly, treatment should be guided by antimicrobial susceptibility testing. Target gene mutations are markedly associated with fluoroquinolone resistance. Knowledge on the genomic characteristics provides valuable insights into in these emerging pathogens.

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Section: Antimicrobial Susceptibility Testing and Antibiotic Resismentioning

confidence: 99%

Elizabethkingia Infections in Humans: From Genomics to Clinics

et al. 2019

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Review on infection control strategies to minimize outbreaks of the emerging pathogen Elizabethkingia anophelis

Mallinckrodt,

Huis in ’t Veld,

Rosema

et al. 2023

Antimicrob Resist Infect Control

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Background Elizabethkingia anophelis is a multi-drug resistant emerging opportunistic pathogen with a high mortality rate, causing healthcare-associated outbreaks worldwide. Methods We report a case of E. anophelis pleuritis, resulting from transmission through lung transplantation, followed by a literature review of outbreak reports and strategies to minimize E. anophelis transmission in healthcare settings. Results From 1990 to August 2022, 14 confirmed E. anophelis outbreak cohorts and 21 cohorts with suspected E. anophelis outbreaks were reported in literature. A total of 80 scientific reports with recommendations on diagnostics and infection control measures were included and summarized in our study. Conclusion Strategies to prevent and reduce spread of E. anophelis include water-free patient rooms, adequate hygiene and disinfection practices, and optimized diagnostic techniques for screening, identification and molecular typing.

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Genome Sequence of Elizabethkingia meningoseptica EM1, Isolated from a Patient with a Bloodstream Infection

Cited by 2 publications

References 10 publications

Elizabethkingia Infections in Humans: From Genomics to Clinics

Elizabethkingia Infections in Humans: From Genomics to Clinics

Review on infection control strategies to minimize outbreaks of the emerging pathogen Elizabethkingia anophelis

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