Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China

Zhang, Qiwei; Seto, Donald; Cao, Bin; Zhao, Suhui; Wan, Chengsong

doi:10.1128/jvi.02225-12

Cited by 49 publications

(52 citation statements)

References 17 publications

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“…We also found emergent HAdV-14 and HAdV-21 and re-emergent HAdV-55 in Southern China, which may have potential to cause more outbreaks in this area, similar with ARD outbreaks in Northern China317182144. Remarkably, we found HAdV-14 emerged in September 2010, one month earlier than the first HAdV-14 strain reported in China21.…”

Section: Discussionsupporting

confidence: 75%

“…Of the seven HAdV species, species B (mostly HAdV-3, -7, -14, and -55) and species E (HAdV-4) are highly associated with ARD, which account for a high proportion of respiratory diseases both in children and adults throughout the world1211121314151617181920212223. HAdV-7 is one of the most important respiratory HAdVs and has been circulating both in military and civilian populations.…”

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confidence: 99%

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Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Zeng

Zhang

et al. 2016

Sci Rep

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Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the United States after a several-decade absence. However, whether HAdV-7d is associated with higher severity than other types is currently unclear. In this study, the clinical and epidemiological investigation showed that fever, cough, and sore throat were the three most common respiratory symptoms of HAdV infections. HAdV-7 caused longer duration of fever, higher morbidity of tachypnea/dyspnea, pleural effusion, diarrhea, hepatosplenomegaly, consciousness alteration, as well as higher rates of pneumonia, mechanical ventilation and higher fatality rate (28.6%) than other types, particularly HAdV-3 and HAdV-2. The genomes of seven HAdV-7d isolates from mild, severe, and fatal cases were sequenced and highly similar with each other. Surprisingly, two isolates (2011, 2012) had 100% identical genomes with an earlier strain from a fatal ARD outbreak in China (2009), which elucidates the virus origin and confirms the unexpected HAdV genomic conservation and stability. Phylogenetic analysis indicated that L1 52/55-kDa DNA packaging protein may be associated with the higher severity of illness and fatality rate of HAdV-7. Clinicians need to be aware of HAdVs in children with ARD.

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Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 99%

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Zeng

Zhang

et al. 2016

Sci Rep

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“…12 It exhibited a neutralizing antigen epitope of HAdV-11 and the pathogenic properties of HAdV-14. [13][14] The whole-genome sequencing analysis showed that HAdV-55 had an HAdV-14 chassis with a partial HAdV-11 in the hexon gene. [15][16] For this reason, it was renamed HAdV-55.…”

Section: Cell Culture and Virus Isolationmentioning

confidence: 99%

Emergence of Community-Acquired Adenovirus Type 55 as a Cause of Community-Onset Pneumonia

Cao

Huang

et al. 2014

Chest

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“…Novel strains may arise from mutations or recombinations of two different adenovirus strains between the hexon gene and fiber genes. 3,4 Recently, an emergent variant, HAdV-55, 5,6 with a proposed recombination of hexon gene between HAdV-11 and HAdV-14 strains, has been described in association with multiple outbreaks of acute respiratory disease, mostly occurring in military camps. [7][8][9][10] In 2005, a large outbreak of acute respiratory disease likely from HAdV-55 occurred in a military camp in Turkey.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009–2012

Tong

et al. 2014

Influenza Resp Viruses

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BackgroundHuman adenovirus 55 (HAdV-55) has caused recent outbreaks of acute respiratory disease (ARD) among adults and military trainees. The active surveillance for HAdV infections was sparse in China, and current knowledge on the HAdV-type distributions and its molecular evolution is lacking.ObjectivesTo acquire better understanding on the prevalence and molecular evolution of HAdV-55 strains in China, for an informed strategy for disease control and prevention.Population/MethodsNasopharyngeal aspirates were collected from hospitalized children with ARTI in Chongqing during 2009–2012. The genotype of HAdV isolates were determined by sequencing the partial hexon and fiber genes. Whole genome sequences of HAdV-55 were obtained for molecular evolution analysis.ResultsAbout 191 (8·55%) HAdV were detected in 2234 children, including 92 (48·2%) with HAdV-7, 72 (37·7%) with HAdV-3, 6 (3·1%) with HAdV-55, 5 (2·6%) with HAdV-5, 4 (2·1%) with HAdV-1, 1 (0·5%) with HAdV-2, and 11(5·8%) with untyped HAdV. Four of these children developed pneumonia, two of whom were diagnosed with severe pneumonia and/or encephalopathy. HAdV-55 isolates clustered with HAdV-11 sequences based on the hexon gene and clustered with HAdV-14 sequences based on the fiber gene and the whole genome. The overall evolutionary rates of hexon gene, fiber gene, and whole genome of HAdV-55 were estimated at 6·2 × 10−5 s/s/y, 8·0 × 10−5 s/s/y, and 1·7 × 10−5 s/s/y, respectively.ConclusionsThis study suggested HAdV-55 as an emerging infectious disease pathogen has conserved genetic structure and is closely related to each other. Further molecular investigation based on HAdV-55 of wider origin might facilitate understanding its diversity, dissemination, and transmission in China.

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Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China

Cited by 49 publications

References 17 publications

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Emergence of Community-Acquired Adenovirus Type 55 as a Cause of Community-Onset Pneumonia

Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009–2012

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