Genome Sequences of Foot-and-Mouth Disease Virus SAT1 and SAT2 Strains from Kenya in 2014 to 2016

Palinski, Rachel; Sangula, Abraham; Gakuya, Francis; Bertram, Miranda R.; Pauszek, Steven J.; Hartwig, E. E.; Smoliga, George R.; Obanda, Vincent; Paul, George; VanderWaal, Kimberly; Arzt, Jonathan

doi:10.1128/mra.00809-19

Cited by 2 publications

(1 citation statement)

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“…The isolates from Burundi from the present study branched separately from viruses isolated in Kenya and Tanzania during the period 2004 to 2016. Approximately between 90 and 91% VP1 nt identity was observed between the serotype SAT2 isolates from Burundi from the present study and a virus isolated in Kenya in September 2014 (SAT2/KEN/K137/2014) [ 41 ], and approximately between 87 and 88% VP1 nt identity was observed with viruses isolated in Tanzania during the period 2012 to 2016 (shown as SAT2/TAN/n/2012 or SAT2/T/n/2016) [ 40 ].…”

Section: Resultsmentioning

confidence: 90%

Outbreaks of Foot-and-Mouth Disease in Burundi, East Africa, in 2016, Caused by Different Serotypes

Garcia

Lefebvre

Nyabongo

et al. 2022

Viruses

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Burundi is a small, densely populated country in the African Great Lakes region. In March 2016, several hundreds of cattle were reported with vesicular lesions, suggesting foot-and-mouth disease (FMD). Epithelial samples, saliva, and blood were collected in six of the affected provinces spread over the country. The overall seroprevalence of FMD virus (FMDV) in the affected herds, as determined by antibodies against FMDV non-structural proteins, was estimated at 87%. Antibodies against FMDV serotypes O (52%), A (44%), C (19%), SAT1 (36%), SAT2 (58%), and SAT3 (23%) were detected across the provinces. FMDV genome was detected in samples from five of the six provinces using rRT-PCR. FMDV was isolated from samples from three provinces: in Cibitoke province, serotypes A and SAT2 were isolated, while in Mwaro and Rutana provinces, only serotype SAT2 was isolated. In Bururi and Cankuzo provinces, the serological profile suggested a recent incursion with serotype SAT2, while in Bubanza province, the serological profile suggested past incursions with serotype O and possibly serotype SAT1. The phylogenetic assessments showed the presence of topotypes A/Africa/G-I and SAT2/IV, similarly to previously characterized virus strains from other countries in the region, suggesting a transboundary origin and necessitating a regional approach for vaccination and control of FMD.

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Section: Resultsmentioning

confidence: 90%