Genome-wide analyses of ATP-Binding Cassette (ABC) transporter gene family and its expression profile related to deltamethrin tolerance in non-biting midge Propsilocerus akamusi

Liu, Wenbin; Sun, Xiaoya; Sun, Wenwen; Zhou, Anmo; Li, Ruoqun; Wang, Bin; Li, Xun; Yan, Chuncai

doi:10.1016/j.aquatox.2021.105940

Cited by 12 publications

(4 citation statements)

References 75 publications

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“…Besides the ABCC subfamily, the numbers of ABCG subfamily genes in all five beetle species in this report are larger compared to other subfamilies, account for 14.4% to 21.5% of ABC transporters. Also, the expansion of ABCG subfamily occurs in most other insect species (Liu et al, 2021; Tian et al, 2017). There are three or four ABCH subfamily genes in genomes of all five tenebrionids, which are comparable to other studied insects other than phloem‐ and blood‐sucking species (Tian et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…We may infer hypotheses about their functions based on their orthologs that have been functionally characterized in other species. The functions of insect ABC transporters from each subfamily have been reviewed (Dermauw & Van Leeuwen, 2014; Liu et al, 2021; Wu et al, 2019). The losses of ABC transporter genes in individual species may support the hypothesis that the missing genes have been lost during beetle evolution, although we cannot suggest a detailed mechanism to account for gene loss.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, ABC transporters have attracted attention by their functional role in Bt toxin resistance (Güney et al, 2021; Heckel, 2020, 2021). ABC transporter genes are associated with other diverse functions such as eye pigmentation, body color, development, molting, cuticle formation, uptake of uric acid, and regulation of circadian clock genes (Broehan et al, 2013; Itoh et al, 2011; W. Liu et al, 2021; Mackenzie et al, 1999; Shang et al, 2020; L. Wang et al, 2013). Yet, functional characterization of ABC transport genes has been focused on detoxification studies in limited numbers of insect species such as D. melanogaster and Tribolium castaneum .…”

Section: Introductionmentioning

confidence: 99%

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Comparative genomic analysis of ABC transporter genes inTenebrio molitorand four other tenebrionid beetles (Coleoptera: Tenebrionidea)

Xiao

Yang

et al. 2022

Arch Insect Biochem Physiol

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ATP-binding cassette (ABC) transporters, one of the largest transmembrane protein families, transport a diverse number of substate across membranes. Details of their diverse physiological functions have not been established. Here, we identified 87 ABC transporter genes in the genomes of Tenebrio molitor along with those from Asbolus verrucosus (104), Hycleus cichorii (65), and Hycleus phaleratus (80).Combining these genes (336 in total) with genes reported in Tribolium castaneum (73), we analyzed the phylogeny of ABC transporter genes in all five Tenebrionids. They are assigned into eight subfamilies (ABCA-H). In comparison to other species, the ABCC subfamily in this group of beetles appears expanded. The expression profiles of the T. molitor genes at different life stages and in various tissues were also investigated using transcriptomic analysis. Most of them display developmental specific expression patterns, suggesting to us their possible roles in development. Most of them are highly expressed in detoxification-related tissues including gut and Malpighian tubule, from which we infer their roles in insecticide resistance. We detected specific or abundant expressions of many ABC transporter genes in various tissues such as salivary gland, ovary, testis,

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative genomic analysis of ABC transporter genes inTenebrio molitorand four other tenebrionid beetles (Coleoptera: Tenebrionidea)

Xiao

Yang

et al. 2022

Arch Insect Biochem Physiol

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“…Approaches to P. akamusi have mostly focused on the transcriptome, proteome, or metabolome [37][38][39][40][41]. However, single omics cannot systematically explain the rapid biochemical reactions and metabolic changes that are expected for acute hypoxia [42,43].…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the Tolerance Mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

Zhang,

et al. 2023

Insects

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Plenty of freshwater species, especially macroinvertebrates that are essential to the provision of numerous ecosystem functions, encounter higher mortality due to acute hypoxia. However, within the family Chironomidae, a wide range of tolerance to hypoxia/anoxia is displayed. Propsilocerus akamusi depends on this great tolerance to become a dominant species in eutrophic lakes. To further understand how P. akamusi responds to acute hypoxic stress, we used multi-omics analysis in combination with histomorphological characteristics and physiological indicators. Thus, we set up two groups—a control group (DO 8.4 mg/L) and a hypoxic group (DO 0.39 mg/L)—to evaluate enzyme activity and the transcriptome, metabolome, and histomorphological characteristics. With blue–black chromatin, cell tightness, cell membrane invagination, and the production of apoptotic vesicles, tissue cells displayed typical apoptotic features in the hypoxic group. Although lactate dehydrogenase (LDH), alcohol dehydrogenase (ADH), catalase (CAT), and Na+/K+ -ATPase (NKA) activities were dramatically enhanced under hypoxic stress, glycogen content, and superoxide dismutase (SOD) activities were significantly reduced compared to the control group. The combined analysis of the transcriptome and metabolome, which further demonstrated, in addition to carbohydrates, including glycogen, the involvement of energy metabolism pathways, including fatty acid, protein, trehalose, and glyoxylate cycles, provided additional support for the aforementioned findings. Lactate is the end product of glycogen degradation, and HIF-1 plays an important role in promoting glycogenolysis in acute hypoxic conditions. However, we discovered that the ethanol tested under hypoxic stress likely originates from the symbiodinium of P. akamusi. These results imply that some parameters related to energy metabolism, antioxidant enzyme activities, and histomorphological features may be used as biomarkers of eutrophic lakes in Chironomus riparius larvae. The study also provides a scientific reference for assessing toxicity and favoring policies to reduce their impact on the environment.

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Response of Propsilocerus akamusi (Diptera: Chironomidae) to the leachates from AMD-contaminated sediments: Implications for metal bioremediation of AMD-polluted areas

Zheng,

Li,

et al. 2024

Aquatic Toxicology

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Genome-wide analyses of ATP-Binding Cassette (ABC) transporter gene family and its expression profile related to deltamethrin tolerance in non-biting midge Propsilocerus akamusi

Cited by 12 publications

References 75 publications

Comparative genomic analysis of ABC transporter genes inTenebrio molitorand four other tenebrionid beetles (Coleoptera: Tenebrionidea)

Comparative genomic analysis of ABC transporter genes inTenebrio molitorand four other tenebrionid beetles (Coleoptera: Tenebrionidea)

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the Tolerance Mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

Response of Propsilocerus akamusi (Diptera: Chironomidae) to the leachates from AMD-contaminated sediments: Implications for metal bioremediation of AMD-polluted areas

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