2022
DOI: 10.1101/2022.05.22.22275428
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Genome-wide analyses of early-onset acute myocardial infarction identify 29 novel loci by whole genome sequencing

Abstract: Early-onset acute myocardial infarction (AMI) may have a higher genetic predisposition than late-onset AMI does. The present study aimed to identify and characterize germline variants that affect early-onset AMI using whole-genome sequencing (WGS). We performed a genome-wide association study based on WGS of 1,239 Koreans, including 596 early-onset AMI patients and 643 healthy individuals. Patients with AMI who underwent percutaneous coronary intervention (PCI) caused by atherothrombotic occlusive lesions were… Show more

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