Genome-wide Ancestry and Demographic History of African-Descendant Maroon Communities from French Guiana and Suriname

Fortes-Lima, César; Gessain, Antoine; Ruiz-Linares, Andrés; Bortolini, Maria-Cátira; Migot-Nabias, Florence; Bellis, Gil; Moreno-Mayar, J. Víctor; Restrepo, Berta Nelly; Rojas, Winston; Avendaño-Tamayo, Efren; Bedoya, Gabriel; Orlando, Ludovic; Salas, Antonio; Helgason, Agnar; Gilbert, M. Thomas P.; Sikora, Martin; Schroeder, Hannes; Dugoujon, Jean‐Michel

doi:10.1016/j.ajhg.2017.09.021

Cited by 57 publications

(68 citation statements)

References 65 publications

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“…To evaluate the impact of sex-biased admixture dynamics in the American populations, we compared the continental ancestry proportions inferred by ADMIXTURE 30 from autosomal data against those estimated for the X chromosome (see Methods). With respect to European ancestry, a paired Wilcoxon test comparing the distribution of autosomal vs X chromosome revealed that the former is significantly higher in all comparisons, suggesting a higher contribution of European males than females in the gene pool of American populations ( Supplementary Figure 8, Supplementary Table 4), in agreement with previous continentalscale reports based on more limited data 25,31,32 . This observation is further supported by the fact that Native American ancestry estimated from autosomal data is always lower (with the exception of Dominican) than that estimated from the X chromosome.…”

Section: Assessing the Impact Of Sex-biased Admixture Of The Americassupporting

confidence: 90%

The genomic impact of European colonization of the Americas

Ongaro

Scliar

Flores

et al. 2019

Preprint

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The human genetic diversity of the Americas has been shaped by several events of gene flow that have continued since the Colonial Era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored.Here we compiled a genome-wide dataset of ~12,000 individuals from twelve American countries and ~6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected i) the genetic structure, ii) the admixture profile, iii) the demographic history and iv) sex-biased geneflow dynamics, of the Americas.We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East and to specific regions of Africa.

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Section: Assessing the Impact Of Sex-biased Admixture Of The Americassupporting

confidence: 90%

The genomic impact of European colonization of the Americas

Ongaro

Scliar

Flores

et al. 2019

Preprint

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“…The legacy of Western Africa on the African genetic diversity in the Americas has been preeminent [55–57], along with an impact of Bantu-influenced populations from Central Western Africa, particularly in Brazil South and the Caribbean [55, 56]. These two African ancestries have also been previously documented in Argentina from studies of autosomal [34] and maternal markers [58, 59].…”

Section: Resultsmentioning

confidence: 96%

Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

Luisi

García

Berros

et al. 2020

Preprint

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Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.Author SummaryThe human genetic diversity in Argentina reflects demographic processes during which the European colonists invaded a territory where Native American populations were settled. During the colonial period, the slave trade also prompted many African people to move to Argentina. Little is known about the origins of these three continental ancestry components in Argentinean populations nowadays. Genotyping data for 87 admixed individuals throughout Argentina was generated and data from the literature was re-analyzed to shed light on this question. We confirmed that most of the European genetic ancestry comes from the South, although several individuals are related to Northern Europeans. We confirmed that the African origins in Argentina mainly trace back from Western and Central/Western regions, and we document some proportion of Eastern African origins poorly described before. As for the Native American ancestry, we identified that it can be divided into four main components that correspond to Central Chile/Patagonia, Subtropical and Tropical Forests, Central Andes and Central Western region of Argentina. In order to understand the specificity of the genetic diversity in Argentina, more effort is required to generate specific massive genomic knowledge at the local level.

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“…Sex-biased ancestry contributions were inferred by comparing the RFMix characterized fractions of each continental ancestry component on the X chromosomes versus the autosomes as previously described 22;23 . For each individual genome, and each ancestry component, the normalized difference between the X chromosome ancestry fraction and the autosomal ancestry fraction ( ΔAdmix ) is defined as: where F anc,total , F anc,X , and F anc,auto are the genome-wide, X chromosome, and autosome ancestry fractions, respectively.…”

Section: Methodsmentioning

confidence: 99%

Cryptic Native American ancestry recapitulates population-specific migration and settlement of the continental United States

Jordan

Rishishwar

Conley

2018

Preprint

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21European and African descendants settled the continental US during the 17 th -19 th centuries, coming into contact 22 with established Native American populations. The resulting admixture among these groups yielded a significant 23 reservoir of cryptic Native American ancestry in the modern US population. We analyzed the patterns of Native 24American admixture seen for the three largest genetic ancestry groups in the US population: African American, 25 European American, and Hispanic/Latino. The three groups show distinct Native American ancestry profiles, 26 which are indicative of their historical patterns of migration and settlement across the country. Native American 27 ancestry in the modern African American population does not coincide with local geography, instead forming a 28 monophyletic group with origins in the southeastern US, consistent with the Great Migration of the early 20 th 29 century. European Americans show Native American ancestry that tracks their geographic origins across the US, 30 indicative of ongoing contact during westward expansion, and Native American ancestry can resolve 31 Hispanic/Latino individuals into distinct local groups formed by more recent migration from Mexico and Puerto 32 Rico. We found an anomalous pattern of Native American ancestry from the US southwest, which most likely 33 corresponds to the Nuevomexicano descendants of early Spanish settlers to the region. We addressed a number 34 of controversies surrounding this population, including the extent of Sephardic Jewish ancestry. Nuevomexicanos 35 are less admixed than nearby Mexican-American individuals, with more European and less Native American and 36 African ancestry, and while they do show demonstrable Sephardic Jewish ancestry, the fraction is no greater than 37 seen for other Hispanic/Latino populations. 38 39 3

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Genome-wide Ancestry and Demographic History of African-Descendant Maroon Communities from French Guiana and Suriname

Cited by 57 publications

References 65 publications

The genomic impact of European colonization of the Americas

The genomic impact of European colonization of the Americas

Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

Cryptic Native American ancestry recapitulates population-specific migration and settlement of the continental United States

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