Genome-wide antibiotic resistance and virulence profiling of Pseudomonas Aeruginosa isolated from clinical samples in Lebanon

Harb, Cynthia P

doi:10.26756/th.2017.25

DOI: 10.26756/th.2017.25

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Genome-wide antibiotic resistance and virulence profiling of Pseudomonas Aeruginosa isolated from clinical samples in Lebanon

Cynthia P Harb¹

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The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals

Nasr,

Abdessamad,

Mina

et al. 2024

Ann Clin Microbiol Antimicrob

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Introduction Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon. Methods We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020. Results Most bacteremias were caused by Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa and Acinetobacter baumannii , with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes. Conclusion This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.

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The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals

Nasr,

Abdessamad,

Mina

et al. 2024

Ann Clin Microbiol Antimicrob

View full text Add to dashboard Cite

show abstract

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Genome-wide antibiotic resistance and virulence profiling of Pseudomonas Aeruginosa isolated from clinical samples in Lebanon

Cited by 1 publication

References 89 publications

The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals

The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals

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