Genome-wide approaches to understanding human ageing

Kaeberlein, Matt

doi:10.1186/1479-7364-2-6-422

Cited by 8 publications

(1 citation statement)

References 99 publications

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“…As noted above, when using erythrocytes as source material, several groups have demonstrated that the genetic signature of long-lived birds shows an enrichment of genes involved in stress defense mechanisms, cell growth and proliferation, and immune function. This agrees generally with data now available from other species with exceptional longevity [135,136], and from studies of long-versus short-lived individuals within species, including humans [137][138][139][140][141]. Genomic profiling has also proven to be a robust predictor of human aging [142].…”

Section: Avian Genomicssupporting

confidence: 88%

New Perspectives on Avian Models for Studies of Basic Aging Processes

Harper

Holmes

2021

Biomedicines

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Avian models have the potential to elucidate basic cellular and molecular mechanisms underlying the slow aging rates and exceptional longevity typical of this group of vertebrates. To date, most studies of avian aging have focused on relatively few of the phenomena now thought to be intrinsic to the aging process, but primarily on responses to oxidative stress and telomere dynamics. But a variety of whole-animal and cell-based approaches to avian aging and stress resistance have been developed—especially the use of primary cell lines and isolated erythrocytes—which permit other processes to be investigated. In this review, we highlight newer studies using these approaches. We also discuss recent research on age-related changes in neural function in birds in the context of sensory changes relevant to homing and navigation, as well as the maintenance of song. More recently, with the advent of “-omic” methodologies, including whole-genome studies, new approaches have gained momentum for investigating the mechanistic basis of aging in birds. Overall, current research suggests that birds exhibit an enhanced resistance to the detrimental effects of oxidative damage and maintain higher than expected levels of cellular function as they age. There is also evidence that genetic signatures associated with cellular defenses, as well as metabolic and immune function, are enhanced in birds but data are still lacking relative to that available from more conventional model organisms. We are optimistic that continued development of avian models in geroscience, especially under controlled laboratory conditions, will provide novel insights into the exceptional longevity of this animal taxon.

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Section: Avian Genomicssupporting

confidence: 88%

New Perspectives on Avian Models for Studies of Basic Aging Processes

Harper

Holmes

2021

Biomedicines

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Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

Mehta

Chandler-Brown

Ramos

et al. 2010

Advances in Experimental Medicine and Biology

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A Genomic Approach to Yeast Chronological Aging

Burtner

Murakami

Kaeberlein

2009

Methods in Molecular Biology

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Yeast is a useful model organism to study the genetic and biochemical mechanisms of aging. Genomic studies of aging in yeast have been limited, however, by traditional methodologies that require a large investment of labor and resources. In this chapter, we describe a newly-developed method for quantitatively measuring the chronological life span of each strain contained in the yeast ORF deletion collection. Our approach involves determining population survival by monitoring outgrowth kinetics using a Bioscreen C MBR shaker/incubator/plate reader. This method has accuracy comparable to traditional assays, while allowing for higher throughput and decreased variability in measurement.

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Genome-wide approaches to understanding human ageing

Cited by 8 publications

References 99 publications

New Perspectives on Avian Models for Studies of Basic Aging Processes

New Perspectives on Avian Models for Studies of Basic Aging Processes

Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

A Genomic Approach to Yeast Chronological Aging

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