Genome-wide association analyses for carcass quality in crossbred beef cattle

Lu, Deren; Sargolzaei, Mehdi; Kelly, Matthew; Voort, Gordon Vander; Wang, Zhiquan; Mandell, I. B.; Moore, S. S.; Plastow, Graham; Miller, Stephen

doi:10.1186/1471-2156-14-80

Cited by 40 publications

(31 citation statements)

References 32 publications

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“…As the sample size is one of the major factors for SNP detection in genome-wide association analysis [24], more samples are needed to detect QTL with strong statistical support, and the detected QTL (SNP) subsequently need to be validated by the addition of more samples. However, this study was in partial agreement with that of Lu et al [25], who found eight SNPs that were associated with hot carcass weight in 747 genotyped animals and 7 of which were located on BTA6. However, 520 SNPs were found significantly associated with mostly individual traits (473 SNPs), and multiple traits (47 SNPs) based on less stringent significance level (p<0.001) and 22 of SNPs out of 48, located on BTA6, were associated Table 8.…”

Section: Discussionsupporting

confidence: 93%

Reduction of slaughter age of Hanwoo steers by early genotyping based on meat yield index

Jeong

Islam

Kim

et al. 2020

Asian-Australas J Anim Sci

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Objective: This study was conducted to determine early hereditary endowment to establish a short-term feeding program.Methods: Hanwoo steers (n = 140) were equally distributed into four groups (35/group) based on genetic meat yield index (MYI) viz. the greatest, great, low, and the lowest at Jukam Hanwoo farm, Goheung. All animals were fed in group pens (5 animals/pen) with similar feed depending on the growth stage. Rice straw was provided ad libitum, whereas concentrate was fed at 5.71 kg during the growing period (6 to 13 mo) and 9.4 kg during the fattening period (13 to 28 mo). Body weight (BW) was measured at two-month intervals, whereas carcass weight was determined at slaughtering at about 31 months of age. The Affymetrix Bovine Axiom Array 640K single nucleotide polymorphism (SNP) chip was used to determine the meat quantity-related gene in the blood.Results: After 6 months, the highest (p<0.05) BW was observed in the greatest MYI group (190.77 kg) and the lowest (p<0.05) in the lowest MYI group (173.51 kg). The great MYI group also showed significantly (p<0.05) higher BW than the lowest MYI group. After 16 and 24 months, the greatest MYI group had the highest BW gain (p<0.05) and were therefore slaughtered the earliest. Carcass weight was significantly (p<0.05) higher in the greatest and the great MYI groups followed by the low and the lowest MYI groups. Back-fat thickness in the greatest MYI group was highly correlated to carcass weight and marbling score. The SNP array analysis identified the carcass-weight related gene BTB-01280026 with an additive effect. The steers with the allele increasing carcass weight had heavier slaughter weight of about 12 kg.Conclusion: Genetic MYI is a potential tool for calf selection, which will reduce the slaughter age while simultaneously increasing carcass weight, back-fat thickness, and marbling score.

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Section: Discussionsupporting

confidence: 93%

Reduction of slaughter age of Hanwoo steers by early genotyping based on meat yield index

Jeong

Islam

Kim

et al. 2020

Asian-Australas J Anim Sci

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“…Carcass weight (CW) and bone weight (BW), important indicators for meat quality and growth status, have been explored by previous studies in livestock (Lu et al . ; Matika et al . ; Guo et al .…”

Section: Significant Snps Identified For Carcass Weight (Cw) In Chinementioning

confidence: 99%

A genome‐wide association study suggests several novel candidate genes for carcass traits in Chinese Simmental beef cattle

et al. 2018

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A genome-wide association study (GWAS) was conducted for two carcass traits in Chinese Simmental beef cattle. The experimental population consisted of 1301 individuals genotyped with the Illumina BovineHD SNP BeadChip (770K). After quality control, 671 990 SNPs and 1217 individuals were retained for the GWAS. The phenotypic traits included carcass weight and bone weight, which were measured after the cattle were slaughtered at 16 to 18 months of age. Three statistical models-a fixed polygene model, a random polygene model and a composite interval mapping polygene model-were used for the GWAS. The genome-wide significance threshold after Bonferroni correction was 7.44E-08 (= 0.05/671 990). In this study, we detected eight and seven SNPs significantly associated with carcass weight and bone weight respectively. In total, 11 candidate genes were identified within or close to these significant SNPs. Of these, we found several novel candidate genes, including PBX1, GCNT4, ALDH1A2, LCORL and WDFY3, to be associated with carcass weight and bone weight in Chinese Simmental beef cattle, and their functional roles need to be verified in further studies.

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“…This procedure has been especially helpful for traits that are hard or expensive to measure and consequently not routinely recorded. Genome-wide association studies (GWAS) aim to identify regions in the genome that are associated with phenotypes and have been applied in many traits including carcass traits [11]. A common method used for GWAS analyses is based on testing one marker at time as fixed effect.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study for Carcass Traits in an Experimental Nelore Cattle Population

et al. 2017

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The purpose of this study was to identify genomic regions associated with carcass traits in an experimental Nelore cattle population. The studied data set contained 2,306 ultrasound records for longissimus muscle area (LMA), 1,832 for backfat thickness (BF), and 1,830 for rump fat thickness (RF). A high-density SNP panel (BovineHD BeadChip assay 700k, Illumina Inc., San Diego, CA) was used for genotyping. After genomic data quality control, 437,197 SNPs from 761 animals were available, of which 721 had phenotypes for LMA, 669 for BF, and 718 for RF. The SNP solutions were estimated using a single-step genomic BLUP approach (ssGWAS), which calculated the variance for windows of 50 consecutive SNPs and the regions that accounted for more than 0.5% of the additive genetic variance were used to search for candidate genes. The results indicated that 12, 18, and 15 different windows were associated to LMA, BF, and RF, respectively. Confirming the polygenic nature of the studied traits, 43, 65, and 53 genes were found in those associated windows, respectively for LMA, BF, and RF. Among the candidate genes, some of them, which already had their functions associated with the expression of energy metabolism, were found associated with fat deposition in this study. In addition, ALKBH3 and HSD17B12 genes, which are related in fibroblast death and metabolism of steroids, were found associated with LMA. The results presented here should help to better understand the genetic and physiologic mechanism regulating the muscle tissue deposition and subcutaneous fat cover expression of Zebu animals. The identification of candidate genes should contribute for Zebu breeding programs in order to consider carcass traits as selection criteria in their genetic evaluation.

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Genome-wide association analyses for carcass quality in crossbred beef cattle

Cited by 40 publications

References 32 publications

Reduction of slaughter age of Hanwoo steers by early genotyping based on meat yield index

Reduction of slaughter age of Hanwoo steers by early genotyping based on meat yield index

A genome‐wide association study suggests several novel candidate genes for carcass traits in Chinese Simmental beef cattle

Genome-Wide Association Study for Carcass Traits in an Experimental Nelore Cattle Population

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