Genome-wide association analysis identifies loci for left-sided displacement of the abomasum in German Holstein cattle

In the present study, a sample of 88 animals belonging to four local (Modicana, Sarda, Sardo-Bruna and Sardo-Modicana) and one cosmopolitan (Italian Brown Swiss) cattle breeds were genotyped with a medium density SNP beadchip and compared to investigate their genetic diversity and the existence of selection signatures. A total of 43 012 SNPs distributed across all 29 autosomal chromosomes were retained after data quality control. Basic population statistics, Wright fixation index and runs of homozygosity (ROH) analyses confirmed that the Italian Brown Swiss genome was shaped mainly by selection, as underlined by the low values of heterozygosity and minor allele frequency. As expected, local cattle exhibited a large within-breed genetic heterogeneity. The F comparison revealing the largest number of significant SNPs was Sardo-Bruna vs. Sardo-Modicana, whereas the smallest was observed for Italian Brown Swiss vs. Sardo-Modicana. Modicana exhibited the largest number of detected ROHs, whereas the smallest was observed for Sardo-Modicana. Signatures of selection were detected in genomic regions that harbor genes involved in milk production traits for Italian Brown Swiss and fitness traits for local breeds. According to the results of multi-dimensional scaling and the admixture analysis the Sardo-Bruna is more similar to the Sarda than to the Italian Brown Swiss breed. Moreover, the Sardo-Modicana is genetically closer to the Modicana than to the Sarda breed. Results of the present work confirm the usefulness of single nucleotide polymorphisms in deciphering the genetic architecture of livestock breeds.

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“…This gene has been found to be associated with the displacement of the abomasum in the German Holstein cattle breed (Mömke et al . ).…”

Section: Discussionmentioning

confidence: 97%

Genome‐wide variability and selection signatures in Italian island cattle breeds

et al. 2018

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“…Die Untersuchungen ergaben, dass DH-Kühe mit LMV einen SNP aufweisen, der eine verminderte Expression des Motilingens zur Folge hat. Mömke et al (16)…”

Section: Genomanalysenunclassified

“…Jahrzehnte an Forschung lieferten eine Vielzahl an Puzzleteilen, um die Pathogenese der Labmagenverlagerung (LMV), die Vielzahl an prädisponierenden Faktoren sowie ihre Folgen und Begleiterscheinungen entschlüsseln und verstehen zu können (6,31). Ausgehend von den anfänglichen Beschreibungen der Erkrankung in den 1950er Jahren (1,18) hat sich die Forschung mittlerweile hauptsächlich der Aufklärung zur Heritabilität der Erkrankung (16,17,23) sowie der pathophysiologischen Zusammenhänge hinsichtlich ihrer Ursachen und Folgen verschrieben (19,20,24,26). Ziel dieses Artikels ist, deutschsprachigen Tierärzten einen Überblick zu neueren Erkenntnissen bezüglich der LMV bei (Milch-)Kühen zu liefern.…”

Section: Introductionunclassified

Labmagenverlagerung beim Rind – kurzer Überblick zu neueren Erkenntnissen

Sickinger

2017

Tierarztl Prax Ausg G

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Understanding abomasal displacement in cattle has been the objective of numerous in-vitro and in-vivo studies. However, a complete elucidation of its pathogenesis has still to be achieved. Nevertheless, a gene test has been developed to diagnose an existing genetic predisposition of individual animals, relying on genomic analyses. An influence of breeding on the incidence of abomasal displacement has become possible, at least within the German Holstein breed, although the test costs remain considerable. According to several studies, distinct laboratory parameters in combination with clinical findings offer the possibility to objectively estimate the (postoperative) prognosis for an individual animal suffering from abomasal displacement.

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“…Eine genetische Korrelation mit der ML lässt sich auch für die linksseitige Labmagenverlagerung (LDA) vermuten (42). Siebzehn SNP (single nuceotide polymorphisms) waren mit der LDA assoziiert und zwei SNP ergaben Beziehungen zum Kalziumstoffwechsel bzw.…”

Section: Genetikunclassified

Leistung und Gesundheit von Milchkühen: Bedeutung von Genetik (Ursache) und Management (Wirkung)

Martens¹

2016

Tierarztl Prax Ausg G

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The milk production of dairy cows has been increased during recent decades through animal-husbandry, improved feeding regime, extensive veterinary service and proper management. It can be assumed that this tendency will be continued in the future. However, the incidence of diseases (production diseases), including ketosis, fat liver, mastitis, lameness, metritis and disturbed fertility, has also increased and exhibits a close genetic correlation with milk yield. The pathogenesis of these diseases is - more or less - causally related to the negative energy balance and hence, is a consequence of selection for high milk yield. The genetic disposition and health risks are modulated by the management of dairy cows and both factors contribute to the large variation of diseases in practice. An analysis of production diseases must therefore distinguish between the genetic disposition (cause) and the management (effect). An effective improvement of the complex of production diseases includes the critical discussion of the current breeding index for dairy cows.

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Genome-wide association analysis identifies loci for left-sided displacement of the abomasum in German Holstein cattle

Cited by 18 publications

References 22 publications

Genome‐wide variability and selection signatures in Italian island cattle breeds

Genome‐wide variability and selection signatures in Italian island cattle breeds

Labmagenverlagerung beim Rind – kurzer Überblick zu neueren Erkenntnissen

Leistung und Gesundheit von Milchkühen: Bedeutung von Genetik (Ursache) und Management (Wirkung)

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