Genome-Wide Association Analysis of <i>Sasang</i> Constitution in the Korean Population

Kim, Bu-Yeo; Jin, Hee-Jeong; Kim, Jong Yeol

doi:10.1089/acm.2010.0764

Cited by 32 publications

(36 citation statements)

References 26 publications

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“…The Affymetrix SNP array 5.0 was used in all KoGES subjects [20] and in 919 KCMS subjects [24], and the UOP genotyping method was used in 2,141 KCMS subjects. First, we screened the 15 replicated SNPs in the KoGES population with 3 lipid parameters such as LDLC, HDLC, and TG, in order to confirm the association of GWAS SNPs with lipid parameters in Koreans.…”

Section: Methodsmentioning

confidence: 99%

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

Chung

Park

et al. 2014

BMC Complement Altern Med

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BackgroundAbnormal lipid concentrations are risk factors for atherosclerosis and cardiovascular disease. The pathological susceptibility to cardiovascular disease risks such as metabolic syndrome, diabetes mellitus, hypertension, insulin resistance, and so on differs between Sasang constitutional types.MethodsWe used multiple regression analyses to study the association between lipid-related traits and genetic variants from several genome-wide association studies according to Sasang constitutional types, considering that the Tae-Eum (TE) has predominant cardiovascular risk.ResultsBy analyzing 26 variants of 20 loci in two Korean populations (8,597 subjects), we found that 12 and 5 variants, respectively, were replicably associated with lipid levels and dyslipidemia risk. By analyzing TE and non-TE type (each 2,664 subjects) populations classified on the basis of Sasang constitutional medicine, we found that the minor allele effects of three variants enriched in TE type had a harmful influence on lipid risk (near apolipoprotein A-V (APOA5)-APOA4-APOC3-APOA1 on increased triglyceride: p = 8.90 × 10-11, in APOE-APOC1-APOC4 on increased low-density lipoprotein cholesterol: p = 1.63 × 10-5, and near endothelial lipase gene on decreased high-density lipoprotein cholesterol: p = 4.28 × 10-3), whereas those of three variants (near angiopoietin-like 3 gene, APOA5-APOA4-APOC3-APOA1, and near lipoprotein lipase gene on triglyceride and high-density lipoprotein cholesterol) associated in non-TE type had neutral influences because of a compensating effect.ConclusionsThese results implied that the minor allele effects of lipid-associated variants may predispose TE type subjects to high cardiovascular disease risk because of their genetic susceptibility to lipid-related disorders.

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Section: Methodsmentioning

confidence: 99%

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

Chung

Park

et al. 2014

BMC Complement Altern Med

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“…Won described a significant link to constitution in chromosomes 8q11.22-23 and 11q22.1-3 based on a genome-wide scan in a Korean family (Won et al, 2009). Kim performed not only genome-wide association analysis but also an analysis of the pathways involved in Sasang constitution (Kim et al, 2012b). Differing from genomic studies, Kim compared gut microbiota based on the Sasang constitutions (Kim et al, 2013b).…”

Section: Somatotype Characteristicsmentioning

confidence: 99%

Recent progress and prospects in Sasang constitutional medicine: A traditional type of physiome-based treatment

Kim¹,

Noble²

2014

Progress in Biophysics and Molecular Biology

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“…In a large family comprising 40 individuals (26 TE, 2 SY, 8 SE, and 4 unknown), 2 genetic loci, 8q11.22-23 and 11q22.1-3, were suggested to be significantly linked with SCM type 17 . Using the genome-wide association study (GWAS) and functional assessment via a text mining-based approach, constitution-associated genes have been identified, including 15 TE-associated, 17 SY-associated, and 12 SE-associated genes 18 . The combination of GWAS with a pathway-based analysis has led to suggestions that several pathways and hub genes that communicate with multiple pathways are distinctly related to SCM type 19 .…”

Section: Sasang Constitutional Perspective and Scientific Evidencementioning

confidence: 99%

Re-interpretation of traditional Asian medicine with constitutional perspective

Pham

Cha

Kim

2013

Integrative Medicine Research

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There has been a rapid increase in tailored medicine that emphasizes the complex inter-individual interactions, and this increase has paralleled recent significant achievements in genomics and Systems Biology. However, attempts to create a virtual human have been limited to low-levels of organization, such as gene-protein networks, due to the lack of systematic concepts at the higher levels of organisms (organ, individual, and environment). Constitutional perspective of various forms of traditional Asian medicine through the ancient, middle, and modern eras, particularly the holistic approach of Sasang constitutional medicine (SCM), may provide a novel framework for creating tailored medicine. This article aims to review the theoretical development of traditional Chinese medicine and the initiation of SCM in addition to summarizing current evidence on the genetic basis, bio-physiological features, and risk of disease of different SCM phenotypes. We also suggest that the patho-physiological principle and scientific evidence underlying SCM, particularly for the TaeEum type, can be effective in dealing with obesity-linked disease, which is a predominant disease in today's society.

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Genome-Wide Association Analysis of Sasang Constitution in the Korean Population

Abstract: Genetic loci and genes associated with Sasang constitution types were systematically identified from a genome-wide association study using a large number of subjects.

Cited by 32 publications

References 26 publications

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

Recent progress and prospects in Sasang constitutional medicine: A traditional type of physiome-based treatment

Re-interpretation of traditional Asian medicine with constitutional perspective

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