Genome wide association studies and prion disease

Lukić, Ana; Mead, Simon

doi:10.4161/pri.5.3.16892

Cited by 2 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, sheep prion disease infection could cross the species barrier and infect bovine but not human. The wellknown acquired human TSE, CJD, is contracted by the human from Bovine (Lukic and Mead, 2011). The common grazing lands, housing, animal handling, and other environmental factors indeed contribute to the entrance of the infection into the food chain parallel to the genotype of individuals exposed to infection (Saunders, Bartelt-Hunt et al 2008, Taskin et al 2010, Pritzkow, Morales et al 2018.…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study for the Determination of Prion Disease for Farm Animals in Ethiopia

2020

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate prion and prion-like disease status of native Ethiopian farm animal. Material and Methods:In this study, descriptive study design was employed. A Semi-Structured interview was conducted to collect primary data from farmers who owned all or either cattle, sheep or goat and animal health extension of the provinces. Simple random sampling and purposive sampling were used to identify farmers who encountered the loss of more than three farm animals from their flock because of the same disease phenotype. Thus, 55 farmers and 6 animal health workers/experts who hold animal science or DVM degree were interviewed.Results: Of the total, 29 of the farmers experienced the loss of a significant number of animals at different times while 10 of them were not able to recall the incidence. All of the participated farmers claimed that there was no prion-like disease that killed dozens of their animals emerged in their areas. Despite the fact that the majority of farmers asked were not able to remember the exact sign and symptom of the disease that was the cause for the death of their animals, they were able to recall the most frequent phenotypes. According to animal health workers; foot and mouth disease (FMD), Lumpy skin disease (LSD) and sheep pox were the major outbreaks detected in the past few years. Conclusion:There were treated and untreated cases of animal diseases having similar clinical signs with that of prion diseases. Though this data has some limitations to conclude that prion disease never happened in the areas where the current study was conducted, it is possible to speculate that there was no epidemic of prion or prion-like disease yet. ÖZ Amaç: Bu çalışma, Etiyopyada çiftlik hayvanlarında prion ve prion benzeri hastalıkların durumunu belirlemek amacıyla yapılmıştır.

show abstract

Section: Introductionmentioning

confidence: 99%

A Preliminary Study for the Determination of Prion Disease for Farm Animals in Ethiopia

2020

View full text Add to dashboard Cite

show abstract

“…2 Studies demonstrate a common polymorphism in the coding region of the PrP gene locus gene (PRNP) at codon 129 is a well-established genetic risk factor for sCJD. 3 Homozygosity at PRNP codon 129 increases the risk of sCJD in Caucasian.…”

Section: Introductionmentioning

confidence: 99%

Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt–Jakob disease

Zhang

et al. 2014

Eur J Hum Genet

View full text Add to dashboard Cite

Pathogenic mitochondrial DNA (mtDNA) mutations leading to mitochondrial dysfunction can cause a variety of chronic diseases in central nervous system (CNS). However, the role of mtDNA mutations in sporadic Creutzfeldt-Jakob disease (sCJD) has still been unknown. In this study, we comparatively analyzed complete mtDNA sequences of 31 Chinese sCJD patients and 32 controls. Using MITOMASTER and PhyloTree, we characterized 520 variants in sCJD patients and 507 variants in control by haplogroup and allele frequencies. We classified the mtDNAs into 40 sub-haplogroups of 5 haplogroups, most of them being Asian-specific haplogroups. Haplogroup U, an European-specific haplogroups mtDNA, was found only in sCJD. The analysis to control region (CR) revealed a 31% increase in the frequency of mtDNA CR mutations in sCJD versus controls. In functional elements of the mtDNA CR, six CR mutations were in conserved sequence blocks I (CSBI) in sCJD, while only one in control (Po0.05). More mutants in transfer ribonucleic acid-Leu (tRNA-Leu) were detected in sCJD. The frequencies of two synonymous amino-acid changes, m.11467A4G, p.( ¼ ) in NADH dehydrogenase subunit 4 (ND4) and m.12372G4A, p.( ¼ ) in NADH dehydrogenase subunit 5 (ND5), in sCJD patients were higher than that of controls. Our study, for the first time, screened the variations of mtDNA of Chinese sCJD patients and identified some potential disease-related mutations for further investigations.

show abstract

Genome wide association studies and prion disease

Cited by 2 publications

References 48 publications

A Preliminary Study for the Determination of Prion Disease for Farm Animals in Ethiopia

A Preliminary Study for the Determination of Prion Disease for Farm Animals in Ethiopia

Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt–Jakob disease

Contact Info

Product

Resources

About