2013
DOI: 10.1371/journal.pone.0066569
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Genome-Wide Association Studies for Growth and Meat Production Traits in Sheep

Abstract: BackgroundGrowth and meat production traits are significant economic traits in sheep. The aim of the study is to identify candidate genes affecting growth and meat production traits at genome level with high throughput single nucleotide polymorphisms (SNP) genotyping technologies.Methodology and ResultsUsing Illumina OvineSNP50 BeadChip, we performed a GWA study in 329 purebred sheep for 11 growth and meat production traits (birth weight, weaning weight, 6-month weight, eye muscle area, fat thickness, pre-wean… Show more

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Cited by 145 publications
(146 citation statements)
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“…Genes that have been reported to influence carcass traits include callipage, myostatin and carwell genes [97,98]. Another study using three different sheep breeds to determine causal variants for growth and meat traits observed significant loci within chromosome 3, 5 and 9 linked to post weaning gain [92] (Table 2). Causal variants TSPEAR (thrombospondin-type laminin G domain and EAR repeat), KRTCAP3 (expressed in the skin keratinocytes) and KIF16B (kinesin family member 16B) influencing wool traits such as fiber diameter, fiber diameter CV and fineness dispersion were confirmed in Chinese Merino sheep breeds [95].…”
Section: Causal Variants Methods Used Referencesmentioning
confidence: 99%
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“…Genes that have been reported to influence carcass traits include callipage, myostatin and carwell genes [97,98]. Another study using three different sheep breeds to determine causal variants for growth and meat traits observed significant loci within chromosome 3, 5 and 9 linked to post weaning gain [92] (Table 2). Causal variants TSPEAR (thrombospondin-type laminin G domain and EAR repeat), KRTCAP3 (expressed in the skin keratinocytes) and KIF16B (kinesin family member 16B) influencing wool traits such as fiber diameter, fiber diameter CV and fineness dispersion were confirmed in Chinese Merino sheep breeds [95].…”
Section: Causal Variants Methods Used Referencesmentioning
confidence: 99%
“…This serves as a backbone for genome wide association studies (GWAS) that can be used to associate phenotypes with causal variants [23,89]. Causal variants have been identified for various traits important for sustainability including reproduction [23], gastrointestinal parasite resistance [90,91], growth and meat production [92][93][94], wool traits [95] and adaptation in extreme environments [96] (Table 2). Table 2.…”
Section: Applying Genomics To Improve Traits Important For Sustainablmentioning
confidence: 99%
“…Мутации, оказывающие влияние на мускулистость (мясистость), т. е. утолщение мышц в соответствии с параметрами скелета, как правило, изменяют траекторию описанной программы развития и меняют число, состав мышечных волокон, а также их гипертрофию. Было выявлено множество мутаций, по-вышающих мускулистость и оказывающих действие на описанную программу развития посредством новых ме-ханизмов (Zhang et al, 2013). Эти мутации представляют собой адекватные модели для изучения формирования и функций мышц (таблица).…”
Section: генетика и селекция животныхunclassified
“…Os estudos de GWAS têm sido empregados para a investigação de várias características complexas e doenças em espécies animais. Para a espécie ovina tem sido utilizado na investigação de doenças como raquitismo, na avaliação de crescimento e produção de carne, bem como para características qualitativas como herança de chifres e cor de pelagem (Zhao et al, 2011;Zhang et al, 2013).…”
Section: A Associação Brasileira Dos Criadores De Ovinos (Arco)unclassified
“…Confirma-se a identidade da sequência BLAST utilizando (GenBank n. de acesso Y13965). Observou-se que todos os animais (Ren et al, 2011;Zhang et al, 2013). Na primeira análise de associação realizada contrastou a variedade negra versus não-negra (vermelhos e brancos), visando identificar fatores genéticos que atuam para a diferenciação fenotípica nessa raça.…”
Section: Sequenciamento De Fragmentos De Mc1runclassified