Genome-wide Association Studies of REST Gene Associated Neurological Diseases/traits with Related Single Nucleotide Polymorphisms

Abstract

Background: Genome-wide association studies (GWAS) have been used to explore the connections between genotypes and phenotypes by comparing the genotype frequencies of genetic changes in individuals with similar origins but distinct traits. Objectives: The aim is to employ the GWAS catalog to identify and investigate the various correlations between genotypes and phenotypes of the REST gene. Method: In this study, we utilized a large dataset of GWAS comprising 62,218,976 individuals in 112 studies and 122 associations with 122 traits (www.ebi.ac.uk/gwas/genes/REST) from European, Asian, Hispanic, African ancestry up to 28 February 2023. Protein-association network evaluation and gene ontology enrichment study was utilized to evaluate the biological function of the discovered gene modules. Results: We identified several associations for both neurodevelopmental and neurodegenerative disorders linked to REST, as well as its mapped gene modules and their functional relationship networks. Conclusion: This work offers fresh insights into identifying risk loci of neurological disorders caused by REST.

Cellular senescence in brain aging and cognitive decline

“…Recently, a GWAS implicated REST and its extended gene network with cognitive decline (Wang et al, 2023), indicating that perhaps genetic variations of REST could account for the betweenindividual variability in the brain aging phenotype. An obvious area of mechanistic exploration would be how REST influences biological aging hallmarks such as cellular senescence.…”

Editorial: Application of genomics and epigenetics in disease and syndrome classification

“…Genomic studies play a pivotal role in identifying genetic variations associated with diseases. Notably, genome-wide association studies have unveiled single nucleotide polymorphisms (SNPs) associated with specific diseases ( Wang et al, 2023 ). In this Research Topic, Liu et al found that miR-196a2 rs11614913 and miR-27a rs895819 may influence genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC).…”