Genome-Wide Association Study Adjusted for Occupational and Environmental Factors for Bladder Cancer Susceptibility

Takeuchi, Takumi; Hattori-Kato, Mami; Okuno, Yukihiro; Zaitsu, Masayoshi; Azuma, Takeshi

doi:10.3390/genes13030448

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Zaitsu et al [9] created a new taxonomy (tentatively named the Zaitsu classification) that combines the classifications of industrial and occupational history to create 12 different categories [15,16].…”

Section: Zaitsu Classification Of Industry/occupationmentioning

confidence: 99%

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A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Takeuchi,

Hattori-Kato,

Okuno

et al. 2024

Cureus

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BackgroundIn addition to genetic predisposition, occupational and environmental factors are important for the risk of prostate cancer. We investigated the effect of single nucleotide polymorphisms (SNPs) on the development of prostate cancer in Japan, including occupational and industrial history as confounding factors in addition to age, smoking, and alcohol drinking. MethodsWe enrolled 210 prostate cancer patients and 504 male control patients. We conducted four genome-wide association study (GWAS) patterns for prostate cancer development. In the association test, logistic regression models incorporated age, smoking history, alcohol consumption history, and each pattern of industrial/occupational classification. ResultsNo SNPs satisfying the genome-wide significance level of 5×10 -8 were detected in GWAS. SNPs with a suggestive association level of 1×10 -6 were found near the long intergenic non-protein coding RNA 1824 (LINC01824) and tripartite motif family like 2 (TRIML2) genes in the GWAS using occupational history as a confounder and near the ribosomal protein S2 pseudogene 25 (RPS2P25) gene in the GWAS using industrial history as a confounder. No SNPs that met the suggestive association level were observed in the GWAS that did not include occupational and industrial history. ConclusionBy adding occupational and industrial history to the confounding factors, there were SNPs detected in the GWAS for prostate cancer development. The consideration of occupational and industrial history may increase the usefulness of GWAS.

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Section: Zaitsu Classification Of Industry/occupationmentioning

confidence: 99%

“…The genotyping of samples, quality control of samples, quality control of genotypes, and SNP imputation were previously described [16].…”

Section: Genotypingmentioning

confidence: 99%

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Takeuchi,

Hattori-Kato,

Okuno

et al. 2024

Cureus

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“…Interestingly, first-degree relatives of patients with BC had a two-fold increased risk of developing this cancer [ 11 , 12 ]. However, a recent genome-wide association study (GWAS) adjusted for occupational and environmental factors for bladder cancer susceptibility confirmed that the influence of genetic factors favouring the development of BC was modified by environmental factors, especially stress stimulation and work environment [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Variability, Expression, and Methylation of IL-6 and IL-8 Genes in Bladder Cancer Pathophysiology

Grębowski

Saluk‐Bijak

Bijak

et al. 2023

IJMS

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Bladder cancer (BC) is the 10th most common form of cancer globally, but its complete aetiology is still unknown. Nevertheless, there is evidence that chronic inflammation plays a role in the development and progression of BC. Therefore, the presented study aimed to detect a potential association between selected single nucleotide polymorphisms (SNPs)—rs1800797 and rs2069845 in IL-6 and rs2227307 in IL-8—and BC development, as well as to identify the impact of BC on the level of expression and methylation of IL-6 and IL-8 promoters in PBMCs with the use of the TaqMan SNP genotyping assay, TaqMan gene expression assay, and methylation-sensitive high-resolution melting techniques. We did not find any association between the genotypes and combined genotypes of all studied polymorphisms and the occurrence of BC. However, we found that BC patients were characterised by decreased IL-6 and IL-8 mRNA expression levels compared to the controls. Additionally, the methylation status of the IL-6 promoter was higher in controls than in BC patients. Our findings suggest that inflammation may be involved in the development and progression of BC.

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Gliomedin drives gastric cancer cell proliferation and migration, correlating with a poor prognosis

You,

Wang,

Wang

et al. 2024

Heliyon

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Genome-Wide Association Study Adjusted for Occupational and Environmental Factors for Bladder Cancer Susceptibility

Cited by 3 publications

References 46 publications

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Variability, Expression, and Methylation of IL-6 and IL-8 Genes in Bladder Cancer Pathophysiology

Gliomedin drives gastric cancer cell proliferation and migration, correlating with a poor prognosis

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