2007
DOI: 10.1038/nature05887
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Genome-wide association study identifies novel breast cancer susceptibility loci

Abstract: Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorp… Show more

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Cited by 2,023 publications
(1,783 citation statements)
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“…Furthermore, targeting FGFR-mediated signaling that acts in an autocrine manner in a subset of breast cancers of poor prognosis has been shown to impair tumor outgrowth and metastasis (Dey et al, 2010). These data, together with observations linking FGFR2 and risk of breast cancer (Easton et al, 2007;Hunter et al, 2007;Meyer et al, 2008), further support that FGFR-mediated signaling is central in breast carcinogenesis.…”
Section: Effect Of 17be2 Through Eramentioning
confidence: 86%
“…Furthermore, targeting FGFR-mediated signaling that acts in an autocrine manner in a subset of breast cancers of poor prognosis has been shown to impair tumor outgrowth and metastasis (Dey et al, 2010). These data, together with observations linking FGFR2 and risk of breast cancer (Easton et al, 2007;Hunter et al, 2007;Meyer et al, 2008), further support that FGFR-mediated signaling is central in breast carcinogenesis.…”
Section: Effect Of 17be2 Through Eramentioning
confidence: 86%
“…This gene encodes a tyrosine kinase receptor and is found to be overexpressed in breast cancer. 47 At the same time, the FGFR2 association was also uncovered by another breast cancer GWAS. 48 One of the well-studied diseases in 2007 was T2D; five novel genetic loci were identified (namely, SLC30A8, HHEX, CDKAL1, CDKN2A/ 2B and IGF2BP2) and robustly confirmed in a number of subsequent studies.…”
Section: The Year Of Gwas: 2007mentioning
confidence: 92%
“…For example, the identification of patients at high risk for developing cancer could lead to advances in screening or chemoprevention. [18][19][20]22,[29][30][31][32] In addition, cancer treatment may be improved when correlations between genotype and clinical outcomes identify subgroups of patients who respond differently to conventional therapy, and these differences may be exploited to individualize choice of therapy or to select optimal doses based on individual differences in drug metabolism or other factors. [33][34][35][36] Ethical issues raised by genome-wide association studies and the role of the Database of Genotypes and Phenotypes…”
Section: Database Of Genotypes and Phenotypesmentioning
confidence: 99%