Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Wei, Qingyi; Yu, Dianke; Liu, Mingbo; Wang, Mengyun; Zhao, Mingqiu; Liu, Ming; Jia, Wei‐Hua; Ma, Hongxia; Fang, Jugao; Xu, Wei; Chen, Kexing; Xu, Zhengang; Wang, Jialing; Tian, Linli; Yuan, Hua; Chang, Jiang; Hu, Zhibin; Wei, Lixun; Huang, Ying; Han, Yaling; Liu, Jie; Han, Demin; Shen, Hongbing; Yang, Shaobo; Zheng, Hong; Ji, Qinghai; Li, Duanshu; Tan, Wen; Wu, Chen; Lin, Dong

doi:10.1038/ng.3090

Cited by 57 publications

(69 citation statements)

References 34 publications

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“…To date, only a GWAS study revealed that FADS1 polymorphism (rs174549) showed a protective effect on LSCC [8]. This finding is consistent with the present results.…”

Section: Discussionsupporting

confidence: 92%

“…This finding is consistent with the present results. Although the mechanism of rs174549 polymorphism on oral cancer is not clear, previous study found there were 49 SNPs in high linkage disequilibrium with rs174549 in the same chromosome, and these SNPs might influence the expression of FADS1 through their effects on host genes [8]. Moreover, FADS1 variation could suppress inflammatory response through influencing the metabolism of PUFAs.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a genome-wide association study (GWAS) identified a new susceptibility loci at fatty acid desaturase 1 ( FADS1 ) gene (rs174549) associated with laryngeal squamous cell carcinoma (LSCC) in Chinese population [8]. FADS1 encodes delta-5 desaturases and is involved in the metabolism of polyunsaturated fatty acids (PUFAs).…”

Section: Introductionmentioning

confidence: 99%

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Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

et al. 2017

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The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes were determined by TaqMan genotyping assay. Non-conditional logistic regression model was used to assess the effects of FADS1 rs174549 polymorphism and fish intake. Subjects carrying A allele of rs174549 significantly reduced the risk of oral cancer (AA VS GG, OR: 0.65, 95% CI: 0.42-0.99; AA VS AG+GG, OR: 0.67, 95% CI: 0.46-0.98). Moreover, the statistically significant reverse associations were especially evident in men, smokers, alcohol drinkers and those age ≤ 60 years. Additionally, fish intake ≥7 times/week showed a 73% reduction in risk for oral cancer compared to those who ate fish less than 2 times/week (OR: 0.27, 95% CI: 0.18-0.42). Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028). This preliminary study suggests that FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction. Functional studies with larger samples are required to confirm our findings.

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“…To date, only a GWAS study revealed that FADS1 polymorphism (rs174549) showed a protective effect on LSCC [8]. This finding is consistent with the present results.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

et al. 2017

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“…The 18 SNPs analyzed here were identified in LC genome-wide association studies [8–10]. All of the SNPs had minor allele frequencies of > 5% in the HapMap for the Chinese Han Beijing population.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, several separate genome-wide association scans have demonstrated that common SNPs, including those in the leucine rich repeat and fibronectin type III domain containing 2 ( LRFN2 ), cyclin-dependent kinase inhibitor 1A ( CDKN1A ), brain-specific angiogenesis inhibitor 3 ( BAI3 ), and parkin RBR E3 ubiquitin protein ligase ( PARK2 ) genes, are associated with LC prognosis. All of these genes are located on Chromosome 5, 6, or 7 [8–10]. …”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Chen

et al. 2016

Oncotarget

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We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15–4.50), 2.17 (1.45–3.25), 2.39 (1.58–3.62), 3.29 (2.10–5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07–2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.

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Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

Zohud,

Lone,

Nashef

et al. 2023

Anim Models and Exp Med

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Head and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year, More than 830 000 people are diagnosed with HNSCC globally, with more than 430 000 fatalities. HNSCC is a deadly diverse malignancy with many tumor locations and biological characteristics. It originates from the squamous epithelium of the oral cavity, oropharynx, nasopharynx, larynx, and hypopharynx. The most frequently impacted regions are the tongue and larynx. Previous investigations have demonstrated the critical role of host genetic susceptibility in the progression of HNSCC. Despite the advances in our knowledge, the improved survival rate of HNSCC patients over the last 40 years has been limited. Failure to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic methods. These results indicate a need to identify more genetic factors underlying this complex disease, which can be better used in early detection and prevention strategies. The lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC tumors. In this report, we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes (e.g. Smad4 and P53 genes) to identify genetic factors affecting the development of this complex disease using genome‐wide association studies, epigenetics, microRNA, long noncoding RNA, lncRNA, histone modifications, methylation, phosphorylation, and proteomics.

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Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Cited by 57 publications

References 34 publications

Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

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