Genome‐wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders

Coleman, Jonathan R. I.; Lester, Kathryn J.; Keers, Robert; Munafò, Marcus R.; Breen, Gerome; Eley, Thalia C.

doi:10.1002/ajmg.b.32558

Cited by 27 publications

(20 citation statements)

References 66 publications

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“…A previous study in the ALSPAC sample, but using the smaller PGC-1-BD GWAS to derive the PRS, also found no evidence of association between the BD-PRS and emotion recognition (Coleman et al, 2017). Our results, using a more powerful BD-PRS, similarly provides little evidence for such a relationship.…”

Section: Interpreting Findings In the Context Of Previous Workcontrasting

confidence: 82%

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Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood

Mistry

Escott‐Price

Florio

et al. 2019

Journal of Affective Disorders

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Introduction Identifying phenotypic manifestations of genetic risk for bipolar disorder (BD) in childhood could increase our understanding of aetiological mechanisms. Aims To examine whether BD genetic risk is associated with childhood (age 8 years) cognitive function. Methods Using data from the Avon Longitudinal Study of Parents and Children, we examined associations between polygenic risk scores for BD (BD-PRS) derived using Psychiatric Genomics Consortium summary data at p-thresholds (P T) 0.01 (primary) and 0.5 (secondary) and several cognitive domains (sample sizes 5,613 to 5,936). We also examined whether associations were due to SNPs that have shared risk effects on schizophrenia (SZ). 2 Results At P T 0.01, the BD-PRS was associated with poorer executive functioning (ß=-0.03, 95%CI-0.06,-0.01; p=0.013), and, more weakly with poorer processing speed (ß =-0.02, 95%CI-0.05, 0.02; p=0.075). Evidence of association with both poorer processing speed (p=0.016) and performance IQ (p=0.018) was stronger at P T 0.5. Associations with performance IQ and processing speed were primarily driven by genetic effects that are shared with schizophrenia SZ risk, but there was some evidence of bipolar-specific genetic effects on childhood executive functioning. Limitations The BD-PRS still explains only a small proportion of the variance for BD which will have reduced power to detect associations. Conclusions Genetic risk for BD manifests as impaired cognition in childhood, and this is driven by risk SNPs that are also shared with schizophrenia SZ genetic risk. Further elucidation of which cognitive domains are most affected by genetic risk for BD could help understanding of aetiology and improve prediction of BD.

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Section: Interpreting Findings In the Context Of Previous Workcontrasting

confidence: 82%

“…To date, only one study has assessed the associations between a BD-PRS and cognitive measures in childhood in the general population. The authors found no association between a BD-PRS and social cognition (Coleman et al, 2017).…”

Section: Introductionmentioning

confidence: 79%

Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood

Mistry

Escott‐Price

Florio

et al. 2019

Journal of Affective Disorders

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“…Three previous studies have investigated the genetic relationships between emotional intelligence, cognitive empathy, and ASD [ 32 – 34 ]. These previous analyses relied on ASD GWAS data from substantially smaller sample sizes than those used herein (N = 46,351 vs .…”

Section: Discussionmentioning

confidence: 99%

“…Three previous studies have investigated the genetic relationships between emotional intelligence, cognitive empathy, and ASD [32][33][34]. These previous analyses relied on ASD GWAS data from substantially smaller sample sizes than those used herein (N = 46,351 vs. N = 10,610 in [32][33][34]). Nevertheless, our data replicate previous nominally significant findings between ASD PRS and negative emotion recognition tasks (e.g., sadness and fear).…”

Section: Plos Geneticsmentioning

confidence: 99%

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort

et al. 2020

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The polygenic nature and the contribution of common genetic variation to autism spectrum disorder (ASD) allude to a high degree of pleiotropy between ASD and other psychiatric and behavioral traits. In a pleiotropic system, a single genetic variant contributes small effects to several phenotypes or disorders. While analyzed broadly, there is a paucity of research studies investigating the shared genetic information between specific neurodevelopmental domains and ASD. We performed a phenome-wide association study of ASD polygenetic risk score (PRS) against 491 neurodevelopmental subdomains ascertained in 4,309 probands from the Philadelphia Neurodevelopmental Cohort (PNC) who lack an ASD diagnosis. Our main analysis calculated ASD PRS in 4,309 PNC probands using the per-SNP effects reported in a recent genome-wide association study of ASD in a case-control design. In a high-resolution manner, our main analysis regressed ASD PRS against 491 neurodevelopmental phenotypes with age, sex, and ten principal components of ancestry as covariates. Follow-up analyses included in the regression model PRS derived from brain-related traits genetically correlated with ASD. Our main finding demonstrated that 11-17-year old probands with the highest ASD genetic risk were able to identify angry faces (R 2 = 1.06%, p = 1.38 × 10 −7 , p Bonferroni-corrected = 1.9 × 10 −3). This ability replicated in older probands (>18 years; R 2 = 0.55%, p = 0.036) and persisted after covarying with other psychiatric disorders, brain imaging traits, and educational attainment (R 2 = 0.2%, p = 0.019). We also detected several suggestive associations between ASD PRS and emotionality and connectedness with others. These data (i) indicate how genetic liability to ASD may influence neurodevelopment in the general population, (ii) reinforce epidemiological findings of heightened ability of ASD cases to predict certain social psychological events based on increased systemizing skills, and (iii) recapitulate theories of imbalance between empathizing and systemizing in ASD etiology.

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“…A small number of studies have shown possible genetic influence on adults' recognition of fear in others (Weiss et al, ). One recent genome‐wide association study of 8‐year‐olds did not reveal any significant specific genes related to children's performance on an ER task (Coleman et al, ). However, in that study, only percentage of correct responses for each emotion (happy, sad, angry, and fearful) were considered.…”

Section: Introductionmentioning

confidence: 97%

A genetically informed examination of the relations between inaccurate emotion expression and recognition and experiencing peer victimization

DiLalla

John

2019

Social Development

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This study examines children's abilities to accurately portray emotions (emotion expression; EE) and to read others' emotions (emotion recognition; ER) as possible genetically influenced behaviors that may increase vulnerability to victimization. In this study of 127 6–10‐year‐old multiples, children were assessed for EE accuracy by being photographed when told to display different emotions; photographs were subsequently rated for emotion accuracy. Children also were assessed for ER accuracy on a computer task by rating the emotions of displayed children's faces. Genetic likelihood scores for angry and fearful EE and ER errors were calculated. Children also completed a victimization questionnaire. Results showed that children who were poor at making angry faces (EE angry misses) were less likely to be victimized, and children who were more likely to rate faces as fearful (ER fearful biases) were more likely to be victimized. ER fearful biases were related to victimization through a shared genetic link. Finally, demonstrating gene–environment correlation, girls with a genetic likelihood for not looking fearful when they were intending to (EE fearful misses) were significantly less likely to be victimized by peers. These results show that emotion skills surrounding expressing and recognizing anger and fear are associated with peer victimization risk.

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Genome‐wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders

Cited by 27 publications

References 66 publications

Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood

Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort

A genetically informed examination of the relations between inaccurate emotion expression and recognition and experiencing peer victimization

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