Genome‐wide DNA methylation analysis along the progression of gastric marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type

Dugge, Rucha; Wagener, Rabea; Möller, Peter; Barth, Thomas F.E.

doi:10.1111/bjh.17193

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Furthermore, aberrant methylation has also been implicated in tumor progression. Dugge et al, investigated the DNA methylation changes associated with progression of gastric MALT lymphoma through genome-wide DNA methylation profiling and observed that 7698 CpG loci associated with 2419 genes were significantly differentially methylated during gastric MALT lymphoma progression [ 218 ]. Among these loci, enrichment of CpGs associated with the promoter was seen and the loci were also enriched in the CpG-rich regions, with most of loci being located within CpG islands [ 219 ].…”

Section: Epigenetics and Methylationmentioning

confidence: 99%

Recent Advances in the Genetic of MALT Lymphomas

Rodríguez‐Sevilla

Salar

2021

Cancers

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Mucosa-associated lymphoid tissue (MALT) lymphomas are a diverse group of lymphoid neoplasms with B-cell origin, occurring in adult patients and usually having an indolent clinical behavior. These lymphomas may arise in different anatomic locations, sharing many clinicopathological characteristics, but also having substantial variances in the aetiology and genetic alterations. Chromosomal translocations are recurrent in MALT lymphomas with different prevalence among different sites, being the 4 most common: t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), and t(3;14)(p14.1;q32). Several chromosomal numerical abnormalities have also been described, but probably represent secondary genetic events. The mutational landscape of MALT lymphomas is wide, and the most frequent mutations are: TNFAIP3, CREBBP, KMT2C, TET2, SPEN, KMT2D, LRP1B, PRDM1, EP300, TNFRSF14, NOTCH1/NOTCH2, and B2M, but many other genes may be involved. Similar to chromosomal translocations, certain mutations are enriched in specific lymphoma types. In the same line, variation in immunoglobulin gene usage is recognized among MALT lymphoma of different anatomic locations. In the last decade, several studies have analyzed the role of microRNA, transcriptomics and epigenetic alterations, further improving our knowledge about the pathogenic mechanisms in MALT lymphoma development. All these advances open the possibility of targeted directed treatment and push forward the concept of precision medicine in MALT lymphomas.

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Section: Epigenetics and Methylationmentioning

confidence: 99%

Recent Advances in the Genetic of MALT Lymphomas

Rodríguez‐Sevilla

Salar

2021

Cancers

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Advances in epigenetic therapies for B-cell non-hodgkin lymphoma

Hu,

Zang,

Feng

et al. 2024

Ann Hematol

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Histomorphologic spectrum of nodal marginal zone lymphoma as defined by its methylome

Spada,

Rosenwald,

Klapper

et al. 2024

American Journal of Clinical Pathology

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Objectives Primary nodal marginal B-cell lymphoma (NMZL) is rare and histologically very variable. Its large-cell presentation is difficult to distinguish from nodal diffuse large B-cell lymphoma (nDLBCL) due to the absence of specific markers for nodal marginal zone lymphomas in general. Methods Using a comprehensive cohort of NMZLs and a control cohort of nDLBCLs, we conducted a methylome analysis on subgroups of both. Results The methylomes were strikingly different between the cohorts but unexpectedly homogeneous within the NMZL cohort. This allowed us to describe the morphologic spectrum of NMZL in all its value ranges. The considerable overlap in growth pattern and cytology of NMZL with nDLBCL was explored morphometrically, leading to an operational tool for separating both by a simple measurement of cell size and nuclear size. This was integrated in a hierarchical approach, including a scoring system for the parameter growth pattern, follicular colonization, follicular dendritic network, IgD expression, and Ki-67 rate, and led to a proposal for a classifier that we present here. Conclusions This methylome-based study extends the morphological spectrum of NMZL towards large cell morphology and offers a conventional way to distinguish it from nDLBCL.

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Genome‐wide DNA methylation analysis along the progression of gastric marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type

Cited by 3 publications

References 13 publications

Recent Advances in the Genetic of MALT Lymphomas

Recent Advances in the Genetic of MALT Lymphomas

Advances in epigenetic therapies for B-cell non-hodgkin lymphoma

Histomorphologic spectrum of nodal marginal zone lymphoma as defined by its methylome

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