2012
DOI: 10.1093/carcin/bgs188
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Genome-wide gene–environment interaction analysis for asbestos exposure in lung cancer susceptibility

Abstract: Asbestos exposure is a known risk factor for lung cancer. Although recent genome-wide association studies (GWASs) have identified some novel loci for lung cancer risk, few addressed genome-wide gene-environment interactions. To determine gene-asbestos interactions in lung cancer risk, we conducted genome-wide gene-environment interaction analyses at levels of single nucleotide polymorphisms (SNPs), genes and pathways, using our published Texas lung cancer GWAS dataset. This dataset included 317 498 SNPs from 1… Show more

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Cited by 45 publications
(40 citation statements)
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“…Little research has been conducted to determine multifactor gene-environment interaction at the candidate gene or genome-wide level despite the emerging evidence to show that these types of complex relationships do exist (1–3). In addition to the lack of studies assessing complex interactions in cancer risk, only a limited number of studies have assessed gene-environment (GE) interactions by histological subtype, as genetic and environmental risk factors have been found to differ by the histology.…”
Section: Introductionmentioning
confidence: 99%
“…Little research has been conducted to determine multifactor gene-environment interaction at the candidate gene or genome-wide level despite the emerging evidence to show that these types of complex relationships do exist (1–3). In addition to the lack of studies assessing complex interactions in cancer risk, only a limited number of studies have assessed gene-environment (GE) interactions by histological subtype, as genetic and environmental risk factors have been found to differ by the histology.…”
Section: Introductionmentioning
confidence: 99%
“…These environmental carcinogens may interact with genetic factors, and since the genetic makeup of each individual is unique, such a gene-environment interaction results in different effects in different individuals [3]. Genetic variations therefore play an equally important role in contributing to individual differences in lung cancer risk.…”
Section: Introductionmentioning
confidence: 99%
“…(22). Therefore we firmly believe that our observed associations should be confirmed in another large, independent study as well as further studies in different populations of individuals with more variation in genetics and exposure.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to exposure factors, genetic polymorphisms are also suspected contributors to cancer development. Some studies have examined interactions between past asbestos exposure and polymorphisms in genes by using either candidate genes approaches (1721) or using whole-genome association approaches (22). …”
Section: Introductionmentioning
confidence: 99%