Genome-wide interaction analysis of folate for colorectal cancer risk

Bouras, Emmanouil; Kim, Andre E.; Lin, Yi; Morrison, John; Du, Mengmeng; Albanes, Demetrius; Barry, Elizabeth L.; Baurley, James W.; Berndt, Sonja I.; Bien, Stephanie A.; Bishop, Timothy D.; Brenner, Hermann; Budiarto, Arif; Burnett-Hartman, Andrea; Campbell, Peter T.; Carreras-Torres, Robert; Casey, Graham; Cenggoro, Tjeng Wawan; Chan, Andrew T.; Chang-Claude, Jenny; Conti, David V.; Cotterchio, Michelle; Devall, Matthew; Diez-Obrero, Virginia; Dimou, Niki; Drew, David A.; Figueiredo, Jane C.; Giles, Graham G.; Gruber, Stephen B.; Gunter, Marc J.; Harrison, Tabitha A.; Hidaka, Akihisa; Hoffmeister, Michael; Huyghe, Jeroen R.; Joshi, Amit D.; Kawaguchi, Eric S.; Keku, Temitope O.; Kundaje, Anshul; Le Marchand, Loic; Lewinger, Juan Pablo; Li, Li; Lynch, Brigid M.; Mahesworo, Bharuno; Männistö, Satu; Moreno, Victor; Murphy, Neil; Newcomb, Polly A.; Obón-Santacana, Mireia; Ose, Jennifer; Palmer, Julie R.; Papadimitriou, Nikos; Pardamean, Bens; Pellatt, Andrew J.; Peoples, Anita R.; Platz, Elizabeth A.; Potter, John D.; Qi, Lihong; Qu, Conghui; Rennert, Gad; Ruiz-Narvaez, Edward; Sakoda, Lori C.; Schmit, Stephanie L.; Shcherbina, Anna; Stern, Mariana C.; Su, Yu-Ru; Tangen, Catherine M.; Thomas, Duncan C.; Tian, Yu; Um, Caroline Y.; van Duijnhoven, Franzel JB.; Van Guelpen, Bethany; Visvanathan, Kala; Wang, Jun; White, Emily; Wolk, Alicja; Woods, Michael O.; Ulrich, Cornelia M.; Hsu, Li; Gauderman, W James; Peters, Ulrike; Tsilidis, Konstantinos K.

doi:10.1016/j.ajcnut.2023.08.010

Cited by 2 publications

(3 citation statements)

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“…Some studies also suggest that a diet poor in fruits, vegetables, and fiber may result in a higher risk of CRC. Epidemiological and experimental evidence highlights the preventive role of folate in carcinogenesis and shows that a higher intake of folic acid is associated with a lower risk of CRC [46,47]. Folic acid participates in DNA biosynthesis, repair, and methylation and plays an important role in cellular homeostasis [46].…”

Section: Environmental Risk Factors For Colorectal Cancermentioning

confidence: 99%

“…Epidemiological and experimental evidence highlights the preventive role of folate in carcinogenesis and shows that a higher intake of folic acid is associated with a lower risk of CRC [46,47]. Folic acid participates in DNA biosynthesis, repair, and methylation and plays an important role in cellular homeostasis [46]. It has been confirmed that a colon microbiome may influence the progression of CRC [48].…”

Section: Environmental Risk Factors For Colorectal Cancermentioning

confidence: 99%

“…Research shows that an imbalance of folate-producing bacteria could contribute to the development of cancer. Therefore, changes in the gut microbiome may mediate or modify the effects of environmental factors on CRC risk [46].…”

Section: Environmental Risk Factors For Colorectal Cancermentioning

confidence: 99%

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Section: Environmental Risk Factors For Colorectal Cancermentioning

confidence: 99%